Genomes and Genes
Gene Symbol: egl-30
Description: hypothetical protein
Species: Caenorhabditis elegans
- Najibi M, Labed S, Visvikis O, IRAZOQUI J. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016;15:1728-42 pubmed publisher..In addition, PKC? was required in macrophages. These observations reveal a previously unknown host defense signaling pathway, which has been conserved across one billion years of evolution. ..
- Greer E, Perez C, Van Gilst M, Lee B, Ashrafi K. Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab. 2008;8:118-31 pubmed publisher..Thus, neural perception of adverse environmental conditions can promote fat accumulation without a concomitant increase in feeding rate. ..
- Liu Y, LeBoeuf B, Garcia L. G alpha(q)-coupled muscarinic acetylcholine receptors enhance nicotinic acetylcholine receptor signaling in Caenorhabditis elegans mating behavior. J Neurosci. 2007;27:1411-21 pubmed..We propose that the GAR-3(mAChR)/G alpha(q) pathway sensitizes the spicule neurons and muscles before and during mating so that the male can respond to hermaphrodite vulva efficiently. ..
- Matsuki M, Kunitomo H, Iino Y. Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2006;103:1112-7 pubmed..Our results suggest that down-regulation of EGL-30-DAG signaling by GOA-1 underlies olfactory adaptation and plasticity of chemotaxis. ..
- Mahoney T, Luo S, Round E, Brauner M, Gottschalk A, Thomas J, et al. Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008;105:16350-5 pubmed publisher..We propose a model whereby the intestinal genes aex-4 and aex-5 control the DMP by regulating the secretion of a signal, which activates the neuronal receptor aex-2. ..
- Yamada K, Hirotsu T, Matsuki M, Kunitomo H, Iino Y. GPC-1, a G protein gamma-subunit, regulates olfactory adaptation in Caenorhabditis elegans. Genetics. 2009;181:1347-57 pubmed publisher..Our analyses place goa-1 Goalpha and let-60 Ras in parallel to gpc-1. In contrast, a gain-of-function mutation in egl-30 Gqalpha was epistatic to gpc-1, suggesting the possibility that gpc-1 Ggamma may act upstream of egl-30 Gqalpha. ..
- McMullan R, Anderson A, Nurrish S. Behavioral and immune responses to infection require G?q- RhoA signaling in C. elegans. PLoS Pathog. 2012;8:e1002530 pubmed publisher..Thus, our data suggests that ligands for Gq coupled receptors are likely to be part of the signals generated in response to M. nematophilum infection. ..
- Chan J, Hu Z, Sieburth D. Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release. Genes Dev. 2012;26:1070-85 pubmed publisher..This study shows that SPHK-1 promotes neurotransmitter release in vivo and identifies a novel muscarinic pathway that regulates SphK abundance at presynaptic terminals. ..
- Pastuhov S, Fujiki K, Nix P, Kanao S, Bastiani M, Matsumoto K, et al. Endocannabinoid-Go? signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gq?-PKC-JNK signalling. Nat Commun. 2012;3:1136 pubmed publisher..Our results show that arachidonoyl ethanolamide induction of a G protein signal transduction pathway has a role in the inhibition of post-development axon regeneration...
- Park E, Horvitz H. Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans. Genetics. 1986;113:821-52 pubmed..elegans would result in a nonmutant phenotype. Second, the dominant effects of mutations in nine of these ten genes are caused by novel gene functions, and in all nine cases the novel function is antagonized by the wild-type function...
- Edwards S, Charlie N, Milfort M, Brown B, Gravlin C, Knecht J, et al. A novel molecular solution for ultraviolet light detection in Caenorhabditis elegans. PLoS Biol. 2008;6:e198 pubmed publisher..Our results reveal a novel molecular solution for ultraviolet light detection and an unusual sensory modality in C. elegans that is unlike any previously described light response in any organism. ..
- Kawli T, Wu C, Tan M. Systemic and cell intrinsic roles of Gqalpha signaling in the regulation of innate immunity, oxidative stress, and longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2010;107:13788-93 pubmed publisher..We propose a model whereby Gqalpha signaling differentially regulates pathogen sensitivity, oxidative stress, and longevity through cell autonomous and noncell autonomous effects on p38 MAPK and insulin/IGF1 signaling, respectively. ..
- Adachi T, Kunitomo H, Tomioka M, Ohno H, Okochi Y, Mori I, et al. Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics. 2010;186:1309-19 pubmed publisher..A putative salt receptor GCY-22 guanylyl cyclase is required in ASER for both salt attraction and avoidance. Our results suggest that ASEL and ASER use distinct molecular mechanisms to regulate salt chemotaxis plasticity. ..
- Qin Y, Zhang X, Zhang Y. A neuronal signaling pathway of CaMKII and Gq? regulates experience-dependent transcription of tph-1. J Neurosci. 2013;33:925-35 pubmed publisher..Together, our work elucidates the molecular and cellular mechanisms whereby experience modulates tph-1 transcription...
- Moghal N, Garcia L, Khan L, Iwasaki K, Sternberg P. Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein Galphaq and excitable cells in C. elegans. Development. 2003;130:4553-66 pubmed