Gene Symbol: egl-27
Description: Egg-laying defective protein 27;hypothetical protein
Alias: Egg-laying defective protein 27;hypothetical protein
Species: Caenorhabditis elegans
Herman M, Ch ng Q, Hettenbach S, Ratliff T, Kenyon C, Herman R. EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans. Development. 1999;126:1055-64 pubmed
..Overlaps in the phenotypes of egl-27 and Wnt pathway mutants suggest that the EGL-27 protein interacts with Wnt signaling pathways in C. elegans. ..
Solari F, Bateman A, Ahringer J. The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning. Development. 1999;126:2483-94 pubmed
..We propose that EGL-27 and EGR-1 function as part of a chromatin regulatory complex required for the function of regional patterning genes. ..
Budovskaya Y, Wu K, Southworth L, Jiang M, Tedesco P, Johnson T, et al
. An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell. 2008;134:291-303 pubmed publisher
..These results identify a transcriptional circuit that guides the rapid aging process in C. elegans and indicate that this circuit is driven by drift of developmental pathways rather than accumulation of damage. ..
Kagias K, Ahier A, Fischer N, Jarriault S. Members of the NODE (Nanog and Oct4-associated deacetylase) complex and SOX-2 promote the initiation of a natural cellular reprogramming event in vivo. Proc Natl Acad Sci U S A. 2012;109:6596-601 pubmed publisher
Kiefer J, Smith P, Mango S. PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut. Dev Biol. 2007;303:611-24 pubmed
..We propose that restriction of early blastomeres to the pharyngeal fate depends on both repression of ectodermal genes and activation of pharyngeal genes by PHA-4. ..
Zuryn S, Ahier A, Portoso M, White E, Morin M, Margueron R, et al
. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science. 2014;345:826-9 pubmed publisher
..Our results draw parallels between epigenetic mechanisms underlying robust Td in nature and efficient cell reprogramming in vitro. ..
Mueller M, Castells Roca L, Babu V, Ermolaeva M, MÃ¼ller R, Frommolt P, et al
. DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol. 2014;16:1168-1179 pubmed publisher
..We propose that EGL-27/GATA activity specifies DAF-16-mediated DNA damage responses to enable developmental progression and to prolong tissue functioning when DNA damage persists. ..
Zahreddine H, Zhang H, Diogon M, Nagamatsu Y, Labouesse M. CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development. Curr Biol. 2010;20:322-7 pubmed publisher
..Our findings should help understand how hemidesmosome dynamics are regulated in vertebrate systems. ..
Xu X, Kim S. The GATA transcription factor egl-27 delays aging by promoting stress resistance in Caenorhabditis elegans. PLoS Genet. 2012;8:e1003108 pubmed publisher
..These results identify egl-27 as a novel factor that links stress and aging pathways...