Gene Symbol: egl-17
Description: hypothetical protein
Species: Caenorhabditis elegans
Burdine R, Chen E, Kwok S, Stern M. egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1997;94:2433-7 pubmed
..We propose that EGL-17 (FGF) acts as a ligand for EGL-15 (FGFR) specifically during SM migration and that another ligand(s) activates EGL-15 for its other functions. ..
Trent C, Tsuing N, Horvitz H. Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics. 1983;104:619-47 pubmed
..At least two of the egl mutants appear to be defective in the processing of environmental signals that modulate egg laying and may define new components of the neural circuitry that control egg laying. ..
Stern M, Horvitz H. A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants. Development. 1991;113:797-803 pubmed
..This incomplete migration is caused by the repulsion of the SMs by the same cells in the somatic gonad that are the source of the attractive signal in wild-type animals. ..
Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed
..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
Birnbaum D, Popovici C, Roubin R. A pair as a minimum: the two fibroblast growth factors of the nematode Caenorhabditis elegans. Dev Dyn. 2005;232:247-55 pubmed
..Phylogenetic and functional studies suggest that LET-756, like vertebrate FGF9, -16, and -20, belongs to the FGF9 family, whereas EGL-17, like vertebrate FGF8, -17, and -18, could be included in the FGF8 family. ..
Fernandes J, Sternberg P. The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva. PLoS Genet. 2007;3:e69 pubmed
..We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types...
Fleming T, Wolf F, Garriga G. Sensitized genetic backgrounds reveal a role for C. elegans FGF EGL-17 as a repellent for migrating CAN neurons. Development. 2005;132:4857-67 pubmed
..This study also raises the possibility that several guidance cues regulate cell migrations along the C. elegans AP axis, and their role in these migrations may only be revealed in sensitized genetic backgrounds. ..
Photos A, Gutierrez A, Sommer R. sem-4/spalt and egl-17/FGF have a conserved role in sex myoblast specification and migration in P. pacificus and C. elegans. Dev Biol. 2006;293:142-53 pubmed
..Mutations in Cel-sem-4 and Cel-egl-17 cause similar defects. Thus, the molecular mechanisms of SM cell specification and migration are conserved between P. pacificus and C. elegans. ..
Klerkx E, Alarcon P, Waters K, Reinke V, Sternberg P, Askjaer P. Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans. Dev Biol. 2009;335:12-21 pubmed publisher
..Expression of a translational VRK-1Colon, two colonsGFP fusion protein in the ventral nerve cord and vulva precursor cells restores vulva and uterus formation, suggesting both cell autonomous and non-autonomous roles of VRK-1. ..