| eel-1Gene Symbol: eel-1 Description: Enhancer of EfL-1 mutant phenotype Alias: Enhancer of EfL-1 mutant phenotype Species: Caenorhabditis elegans Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed ..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure... Page B, Diede S, Tenlen J, Ferguson E. EEL-1, a Hect E3 ubiquitin ligase, controls asymmetry and persistence of the SKN-1 transcription factor in the early C. elegans embryo. Development. 2007;134:2303-14 pubmed ..These data strongly suggest that multiple, functionally redundant pathways cooperate to ensure precise control of SKN-1 asymmetry and persistence in the early embryo. .. Zahreddine H, Zhang H, Diogon M, Nagamatsu Y, Labouesse M. CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development. Curr Biol. 2010;20:322-7 pubmed publisher ..Our findings should help understand how hemidesmosome dynamics are regulated in vertebrate systems. .. Ross A, Li M, Yu B, Gao M, Derry W. The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans. Cell Death Differ. 2011;18:1140-9 pubmed publisher ..Although ee1-1 mutants exhibit hypersensitivity to genotoxic stress they do not appear to be defective in DNA repair, suggesting a distinct role for EEL-1 in promoting damage-induced apoptosis in the germline. .. de Groot R, Ganji R, Bernatik O, Lloyd Lewis B, Seipel K, Sedova K, et al. Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway. Sci Signal. 2014;7:ra26 pubmed publisher ..Our findings indicate that Huwe1 is part of an evolutionarily conserved negative feedback loop in the Wnt/?-catenin pathway. .. Quevedo C, Kaplan D, Derry W. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Curr Biol. 2007;17:286-92 pubmed ..Finally, we show that AKT-1 regulates apoptosis but not cell-cycle progression downstream of the HUS-1/MRT-2 branch of the DNA damage checkpoint. .. Opperman K, Mulcahy B, Giles A, Risley M, Birnbaum R, Tulgren E, et al. The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development. Cell Rep. 2017;19:822-835 pubmed publisher ..These findings from a simple model circuit provide insight into the molecular mechanisms required to obtain E/I balance and could have implications for the link between HUWE1 and intellectual disability. ..
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