Gene Symbol: dyb-1
Description: DYstroBrevin homolog;Dystrobrevin-1
Alias: DYstroBrevin homolog;Dystrobrevin-1
Species: Caenorhabditis elegans

Top Publications

  1. Gieseler K, Bessou C, Segalat L. Dystrobrevin- and dystrophin-like mutants display similar phenotypes in the nematode Caenorhabditis elegans. Neurogenetics. 1999;2:87-90 pubmed
    ..These findings suggest that: (1) dystrobrevin and dystrophin are functionally related and (2) their disruption impairs cholinergic signalling. ..
  2. Gieseler K, Abdel Dayem M, Segalat L. In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin. FEBS Lett. 1999;461:59-62 pubmed
    ..In vitro interaction occurs through the more conserved second helix. We propose a new model of dystrophin interactions with associated proteins. ..
  3. Gieseler K, Mariol M, Bessou C, Migaud M, Franks C, Holden Dye L, et al. Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans. J Mol Biol. 2001;307:107-17 pubmed
    ..All together, these findings further substantiate the role of dystrobrevins in cholinergic transmission and as functional partners of dystrophin. ..
  4. Chen B, Liu P, Zhan H, Wang Z. Dystrobrevin controls neurotransmitter release and muscle Ca(2+) transients by localizing BK channels in Caenorhabditis elegans. J Neurosci. 2011;31:17338-47 pubmed publisher
    ..These observations revealed novel functions of the BK channel in regulating muscle Ca(2+) transients and of dystrobrevin in controlling neurotransmitter release and muscle Ca(2+) transients by localizing the BK channel. ..
  5. Grisoni K, Gieseler K, Mariol M, Martin E, Carre Pierrat M, Moulder G, et al. The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin. J Mol Biol. 2003;332:1037-46 pubmed
    ..These results suggest that the role of syntrophin is linked to dystrophin function in C.elegans. ..
  6. Gieseler K, Grisoni K, Mariol M, Segalat L. Overexpression of dystrobrevin delays locomotion defects and muscle degeneration in a dystrophin-deficient Caenorhabditis elegans. Neuromuscul Disord. 2002;12:371-7 pubmed
    ..This finding indicates that, in C. elegans, (1) the absence of dystrophin can be partly compensated for by extra doses of dystrobrevin, and (2) dystrobrevin is partly functional in absence of dystrophin. ..
  7. Zhou S, Chen L. Neural integrity is maintained by dystrophin in C. elegans. J Cell Biol. 2011;192:349-63 pubmed publisher
    ..elegans. This study provides biochemical data that show that SAX-7 associates with DYS-1 in an STN-2/?-syntrophin-dependent manner. These results reveal a recruitment of L1CAMs to the DPC to ensure neural integrity is maintained. ..
  8. Oh H, Abraham L, van Hengel J, Stove C, Proszynski T, Gevaert K, et al. Interaction of ?-catulin with dystrobrevin contributes to integrity of dystrophin complex in muscle. J Biol Chem. 2012;287:21717-28 pubmed publisher
    ..elegans and mammalian muscles and strongly suggests that this interaction contributes to the integrity of the dystrophin complex. ..
  9. Grisoni K, Gieseler K, Segalat L. Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans. Eur J Biochem. 2002;269:1607-12 pubmed
    ..These deletions also abolished the rescuing activity of a functional transgene in vivo. These results are consistent with a model according to which dystrobrevin must bind to dystrophin to be able to function properly. ..

More Information


  1. Oh K, Abraham L, Gegg C, Silvestri C, Huang Y, Alkema M, et al. Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels. BMC Neurosci. 2015;16:26 pubmed publisher
    ..We suggest that the absence of UNC-2 leads to the reorganization of the cytoskeletal structure that includes CTN-1, which in turn influences SLO-1 puncta localization. ..