Gene Symbol: dsh-2
Description: DiSHevelled related
Alias: DiSHevelled related
Species: Caenorhabditis elegans
Walston T, Tuskey C, Edgar L, Hawkins N, Ellis G, Bowerman B, et al
. Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell. 2004;7:831-41 pubmed
Chang W, Lloyd C, Zarkower D. DSH-2 regulates asymmetric cell division in the early C. elegans somatic gonad. Mech Dev. 2005;122:781-9 pubmed
..We suggest that DSH-2 functions as an upstream regulator of POP-1 in the somatic gonad to control asymmetric cell division, thereby establishing proximal-distal polarity of the developing organ. ..
King R, Maiden S, Hawkins N, Kidd A, Kimble J, Hardin J, et al
. The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway. Dev Biol. 2009;328:234-44 pubmed publisher
..These results indicate that either the DIX or DEP domain of DSH-2 is capable of activating the Wnt/beta-catenin asymmetry pathway and regulating anterior-posterior fate decisions required for proper morphogenesis. ..
Baldwin A, Clemons A, Phillips B. Unique and redundant Î²-catenin regulatory roles of two Dishevelled paralogs during C. elegans asymmetric cell division. J Cell Sci. 2016;129:983-93 pubmed publisher
..Overall, we have further defined the role of Dishevelled in the WÎ²A signaling pathway, and demonstrated that DSH-2 and MIG-5 regulate cell fate, Î²-catenin nuclear levels and the polarity of Î²-catenin regulation. ..
Bei Y, Hogan J, Berkowitz L, Soto M, Rocheleau C, Pang K, et al
. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002;3:113-25 pubmed
..Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell. ..
Hawkins N, Ellis G, Bowerman B, Garriga G. MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions. Dev Biol. 2005;284:246-59 pubmed
..Although all neurons in C. elegans are produced by an invariant pattern of cell divisions, our results indicate that cell signaling may contribute to asymmetric neuroblast division during embryogenesis. ..
Oosterveen T, Coudreuse D, Yang P, Fraser E, Bergsma J, Dale T, et al
. Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev Biol. 2007;308:438-48 pubmed
..We conclude that Axin function in C. elegans is divided over two different Axin orthologs that have specific functions in negatively regulating canonical Wnt signaling. ..
Hingwing K, Lee S, Nykilchuk L, Walston T, Hardin J, Hawkins N. CWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway. Dev Biol. 2009;328:245-56 pubmed publisher
..In particular, DSH-2 function is necessary for the correct production of the embryonic ventral cord motor neurons. This study demonstrates a role for DSH-2 and Wnt signaling in neuronal specification during C. elegans embryogenesis. ..