Gene Symbol: dsh-1
Description: DiSHevelled related
Alias: DiSHevelled related
Species: Caenorhabditis elegans
Song S, Zhang B, Sun H, Li X, Xiang Y, Liu Z, et al
. A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genet. 2010;6: pubmed publisher
..Our study reveals an important role of a Wnt-Frz/Ror-Dsh pathway in regulating neurite A/P outgrowth. ..
Walston T, Tuskey C, Edgar L, Hawkins N, Ellis G, Bowerman B, et al
. Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell. 2004;7:831-41 pubmed
Sanchez Alvarez L, Visanuvimol J, McEwan A, Su A, Imai J, Colavita A. VANG-1 and PRKL-1 cooperate to negatively regulate neurite formation in Caenorhabditis elegans. PLoS Genet. 2011;7:e1002257 pubmed publisher
..Our findings suggest a novel role for a PCP-like pathway in maintaining polarized neuronal morphology by inhibiting neuronal responses to extrinsic or intrinsic cues that would otherwise promote extraneous neurite formation. ..
Zheng C, Diaz Cuadros M, Chalfie M. Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015;112:13243-8 pubmed publisher
..Our results suggest that Dsh proteins both respond to Wnt signals to shape neuronal projections and moderate its activity to fine-tune neuronal morphology. ..
Hawkins N, Ellis G, Bowerman B, Garriga G. MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions. Dev Biol. 2005;284:246-59 pubmed
..Although all neurons in C. elegans are produced by an invariant pattern of cell divisions, our results indicate that cell signaling may contribute to asymmetric neuroblast division during embryogenesis. ..
King R, Maiden S, Hawkins N, Kidd A, Kimble J, Hardin J, et al
. The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway. Dev Biol. 2009;328:234-44 pubmed publisher
..These results indicate that either the DIX or DEP domain of DSH-2 is capable of activating the Wnt/beta-catenin asymmetry pathway and regulating anterior-posterior fate decisions required for proper morphogenesis. ..
Lenfant N, Polanowska J, Bamps S, Omi S, Borg J, Reboul J. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. BMC Genomics. 2010;11:671 pubmed publisher
..The protein interactions from this publication have been submitted to the IMEx (http://www.imexconsortium.org) consortium through IntAct (PMID: 19850723) and assigned the identifier IM-14654]. ..