drh-3

Summary

Gene Symbol: drh-3
Description: Dicer Related Helicase
Alias: Dicer Related Helicase
Species: Caenorhabditis elegans

Top Publications

  1. Claycomb J, Batista P, Pang K, Gu W, Vasale J, Van Wolfswinkel J, et al. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009;139:123-34 pubmed publisher
    ..Instead, our findings support a model in which CSR-1 complexes target protein-coding domains to promote their proper organization within the holocentric chromosomes of C. elegans. ..
  2. Matranga C, Pyle A. Double-stranded RNA-dependent ATPase DRH-3: insight into its role in RNAsilencing in Caenorhabditis elegans. J Biol Chem. 2010;285:25363-71 pubmed publisher
    ..We observe that the DRH-3 ATPase is stimulated only by duplexes containing RNA, suggesting a role for DRH-3 during or after transcription. Our findings provide clues to the role of DRH-3 during the RNA interference response in vivo. ..
  3. Duchaine T, Wohlschlegel J, Kennedy S, Bei Y, Conte D, Pang K, et al. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006;124:343-54 pubmed
    ..Our findings provide a first glimpse at the complex biochemical niche of Dicer and suggest that competition exists between DCR-1-mediated small-RNA pathways. ..
  4. Nakamura M, Ando R, Nakazawa T, Yudazono T, Tsutsumi N, Hatanaka N, et al. Dicer-related drh-3 gene functions in germ-line development by maintenance of chromosomal integrity in Caenorhabditis elegans. Genes Cells. 2007;12:997-1010 pubmed
    ..Taken together, these results indicate that the drh-3 gene is essential for the development of germ-lines by maintaining chromosomal integrity in C. elegans. ..
  5. Aoki K, Moriguchi H, Yoshioka T, Okawa K, Tabara H. In vitro analyses of the production and activity of secondary small interfering RNAs in C. elegans. EMBO J. 2007;26:5007-19 pubmed
    ..An Argonaute protein, CSR-1, is responsible for the Slicer activity induced by secondary-type siRNAs. Secondary rather than primary siRNAs may play a major role in the destabilization of target transcripts during RNAi in C. elegans. ..
  6. van Haaften G, Romeijn R, Pothof J, Koole W, Mullenders L, Pastink A, et al. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. Curr Biol. 2006;16:1344-50 pubmed
  7. Thivierge C, Makil N, Flamand M, Vasale J, Mello C, Wohlschlegel J, et al. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011;19:90-7 pubmed publisher
    ..Our results implicate tudor proteins in the recruitment of RdRP complexes to specific steps within DCR-1-dependent and DCR-1-independent endo-RNAi pathways. ..
  8. Guo X, Zhang R, Wang J, Ding S, Lu R. Homologous RIG-I-like helicase proteins direct RNAi-mediated antiviral immunity in C. elegans by distinct mechanisms. Proc Natl Acad Sci U S A. 2013;110:16085-90 pubmed publisher
  9. Fitzgerald M, Vela A, Pyle A. Dicer-related helicase 3 forms an obligate dimer for recognizing 22G-RNA. Nucleic Acids Res. 2014;42:3919-30 pubmed publisher
    ..This mechanism for RNA length discrimination by a Dicer family protein suggests an alternative model for RNA length measurement by Dicer, with implications for recognition of siRNA and miRNA targets. ..

More Information

Publications10

  1. Andralojc K, Campbell A, Kelly A, Terrey M, Tanner P, Gans I, et al. ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans. PLoS Genet. 2017;13:e1006611 pubmed publisher