Gene Symbol: drh-1
Description: Dicer Related Helicase
Alias: Dicer Related Helicase
Species: Caenorhabditis elegans
Tabara H, Yigit E, Siomi H, Mello C. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 2002;109:861-71 pubmed
..Our findings suggest a model in which RDE-4 and RDE-1 function together to detect and retain foreign dsRNA and to present this dsRNA to DCR-1 for processing. ..
Lightfoot H, Bugaut A, Armisen J, Lehrbach N, Miska E, Balasubramanian S. A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing. Biochemistry. 2011;50:7514-21 pubmed publisher
..The data support a mechanism by which LIN28 can directly inhibit let-7g biogenesis at the Dicer processing step. ..
Guo X, Zhang R, Wang J, Ding S, Lu R. Homologous RIG-I-like helicase proteins direct RNAi-mediated antiviral immunity in C. elegans by distinct mechanisms. Proc Natl Acad Sci U S A. 2013;110:16085-90 pubmed publisher
Lu R, Yigit E, Li W, Ding S. An RIG-I-Like RNA helicase mediates antiviral RNAi downstream of viral siRNA biogenesis in Caenorhabditis elegans. PLoS Pathog. 2009;5:e1000286 pubmed publisher
..elegans control parallel antiviral RNAi pathways. These findings demonstrate both conserved and unique strategies of C. elegans in antiviral defense. ..
Thivierge C, Makil N, Flamand M, Vasale J, Mello C, Wohlschlegel J, et al
. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011;19:90-7 pubmed publisher
..Our results implicate tudor proteins in the recruitment of RdRP complexes to specific steps within DCR-1-dependent and DCR-1-independent endo-RNAi pathways. ..
Coffman S, Lu J, Guo X, Zhong J, Jiang H, Broitman Maduro G, et al
. Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs. MBio. 2017;8: pubmed publisher
..elegans As mammals produce Dicer-dependent viral siRNAs to target RNA viruses, our findings suggest a possible role for mammalian RLRs and interferon signaling in the biogenesis of viral siRNAs. ..