Gene Symbol: dpy-22
Description: Mediator of RNA polymerase II transcription subunit 12
Alias: Mediator of RNA polymerase II transcription subunit 12
Species: Caenorhabditis elegans

Top Publications

  1. DeLong L, Casson L, Meyer B. Assessment of X chromosome dosage compensation in Caenorhabditis elegans by phenotypic analysis of lin-14. Genetics. 1987;117:657-70 pubmed
    ..Additionally, in the case of dpy-21 we correlate the change in phenotypic expression of lin-14 with a corresponding change in the lin-14 mRNA transcript level. ..
  2. Deplancke B, Dupuy D, Vidal M, Walhout A. A gateway-compatible yeast one-hybrid system. Genome Res. 2004;14:2093-101 pubmed
    ..Taken together, the Gateway-compatible Y1H system will allow the high-throughput identification of protein-DNA interactions and may be a valuable tool to decipher transcription regulatory networks. ..
  3. Yoda A, Kouike H, Okano H, Sawa H. Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans. Development. 2005;132:1885-93 pubmed
    ..These results suggest that LET-19 and DPY-22 in the Mediator complex repress the transcription of Wnt target genes. ..
  4. Clayton J, van den Heuvel S, Saito R. Transcriptional control of cell-cycle quiescence during C. elegans development. Dev Biol. 2008;313:603-13 pubmed
    ..These transcriptional regulators represent potential molecular connections between development and the basic cell-cycle machinery. ..
  5. Moghal N, Sternberg P. A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans. Development. 2003;130:57-69 pubmed
    ..Thus, the glutamine-rich region contributes to specificity of this class of mediator protein. ..
  6. Wang J, Walker A, Blackwell T, Yamamoto K. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem. 2004;279:29270-7 pubmed
    ..Interestingly, whereas this interaction has been conserved from yeast to mammals, the subcomplex modulates metazoan-specific genetic pathways, likely in addition to those also controlled in yeast. ..