Gene Symbol: dop-3
Description: Dopamine receptor 3
Alias: Dopamine receptor 3
Species: Caenorhabditis elegans

Top Publications

  1. Ezak M, Ferkey D. The C. elegans D2-like dopamine receptor DOP-3 decreases behavioral sensitivity to the olfactory stimulus 1-octanol. PLoS ONE. 2010;5:e9487 pubmed publisher
    ..Taken together, our data suggest that dopaminergic signaling through DOP-3 normally acts to dampen ASH signaling and behavioral sensitivity to octanol. ..
  2. Suo S, Culotti J, Van Tol H. Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans. EMBO J. 2009;28:2437-48 pubmed publisher
    ..Our results show that C. elegans detects the absence of food by using a small neural circuit composed of three neuron types in which octopaminergic signalling is activated by the cessation of dopamine signalling. ..
  3. Kimura K, Fujita K, Katsura I. Enhancement of odor avoidance regulated by dopamine signaling in Caenorhabditis elegans. J Neurosci. 2010;30:16365-75 pubmed publisher
    ..Thus, our data suggest a new genetic and pharmacological paradigm for nonassociative enhancement of neural responses that is regulated by dopamine signaling. ..
  4. Chase D, Pepper J, Koelle M. Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans. Nat Neurosci. 2004;7:1096-103 pubmed
    ..Our results indicate that extrasynaptic dopamine regulates C. elegans locomotion through D1- and D2-like receptors that activate the antagonistic Galpha(q) and Galpha(o) signaling pathways, respectively. ..
  5. Sugiura M, Fuke S, Suo S, Sasagawa N, Van Tol H, Ishiura S. Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans. J Neurochem. 2005;94:1146-57 pubmed
    ..Reporter gene assay showed that DOP-4 stimulates cAMP accumulation in response to dopamine stimulation. These two receptors provide new opportunities to understand dopaminergic signaling at the molecular level. ..
  6. Barros A, Bridi J, De Souza B, de Castro JĂșnior C, de Lima Torres K, Malard L, et al. Dopamine signaling regulates fat content through ?-oxidation in Caenorhabditis elegans. PLoS ONE. 2014;9:e85874 pubmed publisher
    ..Our findings reveal an ancient role for dopaminergic regulation of fat and suggest that dopamine signaling elicits this outcome through cascades that ultimately mobilize peripheral fat depots. ..
  7. Anyanful A, Easley K, Benian G, Kalman D. Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe. 2009;5:450-62 pubmed publisher
    ..Our findings suggest that the molecular pathways that control innate immunity and lifespan may be regulated or "conditioned" by exposure to pathogens to allow survival in noxious environments. ..
  8. Likhite N, Jackson C, Liang M, Krzyzanowski M, Lei P, Wood J, et al. The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling. Sci Signal. 2015;8:ra115 pubmed publisher
  9. Saharia K, Kumar R, Gupta K, Mishra S, Subramaniam J. Reserpine requires the D2-type receptor, dop-3, and the exoribonuclease, eri-1, to extend the lifespan in C. elegans. J Biosci. 2016;41:689-695 pubmed
    ..This suggests that dop-3 and eri-1 act in independent parallel pathways for RMLE and these two pathways are essential and sufficient for the longevity enhancement by reserpine in C. elegans. ..

More Information


  1. Topalidou I, Cooper K, Pereira L, Ailion M. Dopamine negatively modulates the NCA ion channels in C. elegans. PLoS Genet. 2017;13:e1007032 pubmed publisher
    ..Finally, we demonstrate that dopamine, through DOP-3, negatively regulates NCA activity. Thus, this study identifies a pathway by which dopamine modulates the activity of the NCA channels...