Gene Symbol: dnc-2
Description: Probable dynactin subunit 2
Alias: Probable dynactin subunit 2
Species: Caenorhabditis elegans

Top Publications

  1. Zhang H, Skop A, White J. Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos. J Cell Sci. 2008;121:155-61 pubmed publisher
    ..By RNAi of a weak dnc-1(ts) allele, we showed that dynactin activity was required at least for EMS spindle rotational alignment. ..
  2. Ai E, Poole D, Skop A. RACK-1 directs dynactin-dependent RAB-11 endosomal recycling during mitosis in Caenorhabditis elegans. Mol Biol Cell. 2009;20:1629-38 pubmed publisher
    ..Our findings suggest a mechanism by which RACK-1 directs the dynactin-dependent redistribution of recycling endosomes during the cell cycle, thus ensuring proper membrane trafficking events during cytokinesis. ..
  3. Skop A, White J. The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos. Curr Biol. 1998;8:1110-6 pubmed
    ..Dynactin complexes may serve as a tether for dynein at the cortex and allow dynein to produce forces on the astral microtubules required for mitotic spindle alignment. ..
  4. Gassmann R, Essex A, Hu J, Maddox P, Motegi F, Sugimoto A, et al. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008;22:2385-99 pubmed publisher
  5. Ai E, Poole D, Skop A. Long astral microtubules and RACK-1 stabilize polarity domains during maintenance phase in Caenorhabditis elegans embryos. PLoS ONE. 2011;6:e19020 pubmed publisher
    ..We found a correlation between short astral microtubules and the instability of PAR-6 and PAR-2 domains during maintenance phase. Our data support a necessary role for astral microtubules in the maintenance phase of cell polarity. ..
  6. Dinkelmann M, Zhang H, Skop A, White J. SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria. Genetics. 2007;177:1609-20 pubmed
    ..elegans. To our knowledge, SPD-3 is the first example of a link between mitochondria and spindle alignment in C. elegans. ..
  7. Terasawa M, Toya M, Motegi F, Mana M, Nakamura K, Sugimoto A. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Genes Cells. 2010;15:1145-57 pubmed publisher
    ..These results suggest that DNC-3 is essential for the formation of the projection arm subcomplex of dynactin. ..