Gene Symbol: dnc-1
Description: DyNactin Complex component
Alias: DyNactin Complex component
Species: Caenorhabditis elegans
Skop A, White J. The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos. Curr Biol. 1998;8:1110-6 pubmed
..Dynactin complexes may serve as a tether for dynein at the cortex and allow dynein to produce forces on the astral microtubules required for mitotic spindle alignment. ..
Zhang H, Skop A, White J. Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos. J Cell Sci. 2008;121:155-61 pubmed publisher
..By RNAi of a weak dnc-1(ts) allele, we showed that dynactin activity was required at least for EMS spindle rotational alignment. ..
Terasawa M, Toya M, Motegi F, Mana M, Nakamura K, Sugimoto A. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Genes Cells. 2010;15:1145-57 pubmed publisher
..These results suggest that DNC-3 is essential for the formation of the projection arm subcomplex of dynactin. ..
Hsu C, Moncaleano J, Wagner O. Sub-cellular distribution of UNC-104(KIF1A) upon binding to adaptors as UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-?) in C. elegans neurons. Neuroscience. 2011;176:39-52 pubmed publisher
..On the other hand, if UNC-104 is bound to SYD-2 we identify motor populations mostly along axons. Therefore, these three adaptors inherit different functions in steering the motor to specific sub-cellular locations in the neuron. ..
Aguirre Chen C, Bülow H, Kaprielian Z. C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development. 2011;138:507-18 pubmed publisher
Barbosa D, Duro J, Prevo B, Cheerambathur D, Carvalho A, Gassmann R. Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport. PLoS Genet. 2017;13:e1006941 pubmed publisher
Dinkelmann M, Zhang H, Skop A, White J. SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria. Genetics. 2007;177:1609-20 pubmed
..elegans. To our knowledge, SPD-3 is the first example of a link between mitochondria and spindle alignment in C. elegans. ..
Ikenaka K, Kawai K, Katsuno M, Huang Z, Jiang Y, Iguchi Y, et al
. dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration. PLoS ONE. 2013;8:e54511 pubmed publisher
..Thus, our results suggest that decreased expression of dynactin 1 induces motor neuron degeneration and that the transport of autophagosomes is a novel and substantial therapeutic target for motor neuron degeneration...