Gene Symbol: dlc-1
Description: Dynein light chain 1, cytoplasmic
Alias: Dynein light chain 1, cytoplasmic
Species: Caenorhabditis elegans
Dorsett M, Schedl T. A role for dynein in the inhibition of germ cell proliferative fate. Mol Cell Biol. 2009;29:6128-39 pubmed publisher
..Our results add a new dimension to the processes controlled by the dynein motor complex, demonstrating that dynein can act as an antiproliferative factor. ..
Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al
. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed
..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
Fridolfsson H, Ly N, Meyerzon M, Starr D. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Dev Biol. 2010;338:237-50 pubmed publisher
..Kinesin-1 functions as the major force generator during nuclear migration, while dynein is involved in regulation of bidirectional transport of the nucleus. ..
Morthorst T, Olsen A. Cell-nonautonomous inhibition of radiation-induced apoptosis by dynein light chain 1 in Caenorhabditis elegans. Cell Death Dis. 2013;4:e799 pubmed publisher
..Our results strengthen the notion of a highly dynamic communication between somatic cells and germ cells in regulating the apoptotic process. ..
Erdélyi P, Borsos E, Takacs Vellai K, Kovacs T, Kovacs A, Sigmond T, et al
. Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J Cell Sci. 2011;124:1510-8 pubmed publisher
..The identification of apoptosis and autophagy as compensatory cellular pathways in C. elegans might help us to understand how dysregulated PCD in humans can lead to diverse pathologies, including cancer, neurodegeneration and diabetes. ..
Wang X, Olson J, Rasoloson D, Ellenbecker M, Bailey J, Voronina E. Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells. Development. 2016;143:4643-4653 pubmed
..Furthermore, these results identify a new role for DLC-1 in post-transcriptional regulation of gene expression. ..