Gene Symbol: dkf-2
Description: Serine/threonine-protein kinase dkf-2
Alias: Serine/threonine-protein kinase dkf-2
Species: Caenorhabditis elegans

Top Publications

  1. Fu Y, Ren M, Feng H, Chen L, Altun Z, Rubin C. Neuronal and intestinal protein kinase d isoforms mediate Na+ (salt taste)-induced learning. Sci Signal. 2009;2:ra42 pubmed publisher
    ..Thus, pathways containing EGL-8-TPA-1-DKF-2 enable learning and behavioral plasticity by receiving, transmitting, and cooperatively integrating environmental signals targeted to both neurons and intestine. ..
  2. Feng H, Ren M, Chen L, Rubin C. Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span. J Biol Chem. 2007;282:31273-88 pubmed
    ..The results suggest a mechanism for increased longevity and show that a PKD links DAG signals to regulation of stress responses and life span. ..
  3. Ren M, Feng H, Fu Y, Land M, Rubin C. Protein kinase D is an essential regulator of C. elegans innate immunity. Immunity. 2009;30:521-32 pubmed publisher
    ..Thus, a PKD mobilizes activation of host immune defenses against pathogens by previously unappreciated signaling pathways and mechanisms. ..
  4. Aicart Ramos C, He S, Land M, Rubin C. A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY. J Biol Chem. 2016;291:23516-23531 pubmed
    ..Overall, the structural integrity and function of the novel dimerization domain are essential for PKD-mediated regulation of a key aspect of cell physiology, secretion, and innate immunity in vivo. ..

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