dkf-1

Summary

Gene Symbol: dkf-1
Description: Serine/threonine-protein kinase dkf-1
Alias: Serine/threonine-protein kinase dkf-1
Species: Caenorhabditis elegans

Top Publications

  1. Feng H, Ren M, Rubin C. Conserved domains subserve novel mechanisms and functions in DKF-1, a Caenorhabditis elegans protein kinase D. J Biol Chem. 2006;281:17815-26 pubmed
    ..Persistent phosphorylation of Thr(588) (activation loop) promoted ubiquitinylation and proteasome-mediated degradation of DKF-1. Each DKF-1 domain displayed novel properties indicative of functional malleability (plasticity). ..
  2. Feng H, Ren M, Wu S, Hall D, Rubin C. Characterization of a novel protein kinase D: Caenorhabditis elegans DKF-1 is activated by translocation-phosphorylation and regulates movement and growth in vivo. J Biol Chem. 2006;281:17801-14 pubmed
    ..Targeted DKF-1 expression corrected this locomotory defect in dkf-1 null animals. Supraphysiological expression of DKF-1 limited C. elegans growth to approximately 60% of normal length. ..
  3. Feng H, Ren M, Chen L, Rubin C. Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span. J Biol Chem. 2007;282:31273-88 pubmed
    ..The results suggest a mechanism for increased longevity and show that a PKD links DAG signals to regulation of stress responses and life span. ..
  4. Najibi M, Labed S, Visvikis O, IRAZOQUI J. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016;15:1728-42 pubmed publisher
    ..In addition, PKC? was required in macrophages. These observations reveal a previously unknown host defense signaling pathway, which has been conserved across one billion years of evolution. ..