Gene Symbol: dhc-3
Description: Dynein Heavy Chain
Alias: Dynein Heavy Chain
Species: Caenorhabditis elegans
Products:     dhc-3

Top Publications

  1. Nguyen Ngoc T, Afshar K, GONCZY P. Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans. Nat Cell Biol. 2007;9:1294-302 pubmed
    ..Together with microtubule dynamics, this allows pulling forces to be exerted and proper cell division to be achieved. ..
  2. van der Voet M, Berends C, Perreault A, Nguyen Ngoc T, GONCZY P, Vidal M, et al. NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat Cell Biol. 2009;11:269-77 pubmed publisher
    ..These functional interactions may be conserved in mammals, with implications for primary microcephaly. ..
  3. Zhou K, Rolls M, Hall D, Malone C, Hanna Rose W. A ZYG-12-dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad. J Cell Biol. 2009;186:229-41 pubmed publisher
  4. Boulton S, Martin J, Polanowska J, Hill D, Gartner A, Vidal M. BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans. Curr Biol. 2004;14:33-9 pubmed
    ..Our findings support a shared role for Ce-BRC-1 and Ce-BRD-1 in C. elegans DNA repair processes, and this role will permit studies of the BRCA1 pathway in an organism amenable to rapid genetic and biochemical analysis. ..
  5. Gusnowski E, Srayko M. Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning. J Cell Biol. 2011;194:377-86 pubmed publisher
    ..We propose a model whereby different dynein-MT interactions are used for specific spindle-positioning tasks in the one-cell embryo. ..