Gene Symbol: dhc-1
Description: Dynein Heavy Chain;Dynein heavy chain, cytoplasmic
Alias: Dynein Heavy Chain;Dynein heavy chain, cytoplasmic
Species: Caenorhabditis elegans

Top Publications

  1. Zhou K, Rolls M, Hall D, Malone C, Hanna Rose W. A ZYG-12-dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad. J Cell Biol. 2009;186:229-41 pubmed publisher
  2. Schmidt D, Rose D, Saxton W, Strome S. Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol Biol Cell. 2005;16:1200-12 pubmed
    ..This suggests that temperature-sensitive mutations can be created for time-resolved function analyses of dyneins and perhaps other P-loop proteins in a variety of model systems. ..
  3. Hannak E, Oegema K, Kirkham M, GONCZY P, Habermann B, Hyman A. The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent. J Cell Biol. 2002;157:591-602 pubmed
    ..Thus, although unknown mechanisms can support partial assembly of mitotic centrosomal asters, gamma-tubulin is the kinetically dominant centrosomal MT nucleator. ..
  4. Tarailo Graovac M, Wong T, Qin Z, Flibotte S, Taylor J, Moerman D, et al. Cyclin B3 and dynein heavy chain cooperate to increase fitness in the absence of mdf-1/MAD1 in Caenorhabditis elegans. Cell Cycle. 2014;13:3089-199 pubmed publisher
    ..We also show that amplification of cyb-3 and dhc-1(dot168) cooperate to increase fitness in the absence of MDF-1. ..
  5. Park M, Watanabe S, Poon V, Ou C, Jorgensen E, Shen K. CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron. 2011;70:742-57 pubmed publisher
  6. Arimoto M, Koushika S, Choudhary B, Li C, Matsumoto K, Hisamoto N. The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J Neurosci. 2011;31:2216-24 pubmed publisher
    ..Thus, UNC-16 functions as an adaptor for kinesin-1-mediated transport of dynein. ..
  7. Barbosa D, Duro J, Prevo B, Cheerambathur D, Carvalho A, Gassmann R. Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport. PLoS Genet. 2017;13:e1006941 pubmed publisher
  8. Goodwin P, Sasaki J, Juo P. Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J Neurosci. 2012;32:8158-72 pubmed publisher
    ..We propose a model in which CDK-5 regulates DCV polarity by both promoting DCV trafficking in axons and preventing dynein-dependent DCV trafficking into dendrites. ..
  9. Aguirre Chen C, B├╝low H, Kaprielian Z. C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development. 2011;138:507-18 pubmed publisher

More Information


  1. Fortin S, Marshall S, Jaeger E, Greene P, Brady L, Isaac R, et al. The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos. Dev Biol. 2010;344:992-1000 pubmed publisher
    ..We conclude that PAM-1's role in axis polarization is to prevent premature movement of the centrosome from the posterior cortex, ensuring proper axis establishment in the embryo...
  2. Locke C, Williams S, Schwarz E, Caldwell G, Caldwell K. Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 2006;1120:23-34 pubmed
    ..Thus, interactions among gene products with LIS-1 may mediate intrinsic thresholds of neuronal synchrony. ..
  3. Yang H, Mains P, McNally F. Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. J Cell Biol. 2005;169:447-57 pubmed
    ..This study thus reveals two sequential mechanisms for translocating anastral spindles to the oocyte cortex. ..
  4. Portereiko M, Saam J, Mango S. ZEN-4/MKLP1 is required to polarize the foregut epithelium. Curr Biol. 2004;14:932-41 pubmed
    ..Microtubules and actin are disorganized in zen-4 mutants compared to the wild-type. We suggest that ZEN-4/MKLP1 and CYK-4/RhoGAP regulate an early step in epithelial polarization that is required to establish the apical domain and CeAJ. ..
  5. Dorsett M, Schedl T. A role for dynein in the inhibition of germ cell proliferative fate. Mol Cell Biol. 2009;29:6128-39 pubmed publisher
    ..Our results add a new dimension to the processes controlled by the dynein motor complex, demonstrating that dynein can act as an antiproliferative factor. ..
  6. Cockell M, Baumer K, GONCZY P. lis-1 is required for dynein-dependent cell division processes in C. elegans embryos. J Cell Sci. 2004;117:4571-82 pubmed
    ..These results suggest that dynein and Lis1, albeit functioning in identical processes, are targeted partially independently of one another. ..
  7. Fridolfsson H, Ly N, Meyerzon M, Starr D. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Dev Biol. 2010;338:237-50 pubmed publisher
    ..Kinesin-1 functions as the major force generator during nuclear migration, while dynein is involved in regulation of bidirectional transport of the nucleus. ..
  8. Kimura A, Onami S. Computer simulations and image processing reveal length-dependent pulling force as the primary mechanism for C. elegans male pronuclear migration. Dev Cell. 2005;8:765-75 pubmed
    ..A male pronucleus having a single centrosome migrated toward the single aster. We propose that the pulling mechanism is the primary mechanism for male pronuclear migration. ..
  9. Ellefson M, McNally F. Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans. Mol Biol Cell. 2009;20:2722-30 pubmed publisher
    ..This represents a case of kinesin-1/dynein coordination in which these two motors of opposite polarity act sequentially and independently on a cargo to move it in the same direction. ..
  10. van der Voet M, Berends C, Perreault A, Nguyen Ngoc T, GONCZY P, Vidal M, et al. NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat Cell Biol. 2009;11:269-77 pubmed publisher
    ..These functional interactions may be conserved in mammals, with implications for primary microcephaly. ..
  11. Gassmann R, Essex A, Hu J, Maddox P, Motegi F, Sugimoto A, et al. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008;22:2385-99 pubmed publisher
  12. Kotak S, Busso C, G nczy P. Cortical dynein is critical for proper spindle positioning in human cells. J Cell Biol. 2012;199:97-110 pubmed publisher
    ..Overall, we propose a model in which the ternary complex serves to anchor dynein at the plasma membrane to ensure correct spindle positioning...
  13. Schmidt R, Fielmich L, Grigoriev I, Katrukha E, Akhmanova A, van den Heuvel S. Two populations of cytoplasmic dynein contribute to spindle positioning in C. elegans embryos. J Cell Biol. 2017;216:2777-2793 pubmed publisher
  14. Tsou M, Hayashi A, DeBella L, McGrath G, Rose L. LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos. Development. 2002;129:4469-81 pubmed
    ..Together, the data indicate that LET-99 acts downstream of PAR-3 and PAR-2 to determine spindle positioning, potentially through the asymmetric regulation of forces on the spindle. ..