Research Topics

Genomes and Genes



Gene Symbol: des-2
Description: Acetylcholine receptor subunit alpha-type des-2;DEgeneration Suppressor
Alias: Acetylcholine receptor subunit alpha-type des-2;DEgeneration Suppressor
Species: Caenorhabditis elegans

Top Publications

  1. Cohen Ben Ami H, Biala Y, Farah H, Elishevitz E, Battat E, Treinin M. Receptor and subunit specific interactions of RIC-3 with nicotinic acetylcholine receptors. Biochemistry. 2009;48:12329-36 pubmed publisher
    ..Such differences may explain both the effects of RIC-3 on receptor properties and the differences in its effects on different receptors. ..
  2. Oren Suissa M, Hall D, Treinin M, Shemer G, Podbilewicz B. The fusogen EFF-1 controls sculpting of mechanosensory dendrites. Science. 2010;328:1285-8 pubmed publisher
    ..Neuronal pruning appeared to involve EFF-1-dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees...
  3. Ben Ami H, Yassin L, Farah H, Michaeli A, Eshel M, Treinin M. RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains. J Biol Chem. 2005;280:28053-60 pubmed
    ..Together our results suggest that subunit-specific interactions of RIC-3 with nAChR subunits, mediated by the transmembrane domains, are sufficient for the effects of RIC-3 on nAChR quantity and quality. ..