ddl-2

Summary

Gene Symbol: ddl-2
Description: Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased)
Alias: Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased)
Species: Caenorhabditis elegans

Top Publications

  1. Hansen M, Hsu A, Dillin A, Kenyon C. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 2005;1:119-28 pubmed
    ..Thus, our current view of the genetics of aging has probably not been distorted substantially by selection bias. ..
  2. Chiang W, Ching T, Lee H, Mousigian C, Hsu A. HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. Cell. 2012;148:322-34 pubmed publisher
    ..Both the formation of DHIC and the phosphorylation of DDL-1 are controlled by IIS. Our findings point to DDL-1/2 as a link between IIS and the HSF-1 pathway. ..