Gene Symbol: dcr-1
Description: Death-promoting deoxyribonuclease
Alias: Death-promoting deoxyribonuclease
Species: Caenorhabditis elegans
Products:     dcr-1

Top Publications

  1. Ketting R, Fischer S, Bernstein E, Sijen T, Hannon G, Plasterk R. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 2001;15:2654-9 pubmed
    ..dcr-1 mutants show a defect in RNAi. Furthermore, a combination of phenotypic abnormalities and RNA analysis suggests a role for dcr-1 in a regulatory pathway comprised of small temporal RNA (let-7) and its target (e.g., lin-41). ..
  2. Newbury S, Woollard A. The 5'-3' exoribonuclease xrn-1 is essential for ventral epithelial enclosure during C. elegans embryogenesis. RNA. 2004;10:59-65 pubmed
    ..elegans. We have also investigated whether xrn-1 can influence the response of C. elegans to RNA interference. Our data indicate that xrn-1 plays a facilitating, but not crucial role in this process. ..
  3. Drake M, Furuta T, Suen K, Gonzalez G, Liu B, Kalia A, et al. A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans. Dev Cell. 2014;31:614-28 pubmed publisher
  4. Juang B, Gu C, Starnes L, Palladino F, Goga A, Kennedy S, et al. Endogenous nuclear RNAi mediates behavioral adaptation to odor. Cell. 2013;154:1010-1022 pubmed publisher
    ..This class of siRNA may act broadly as a rheostat allowing prolonged stimulation to dampen gene expression and promote cellular memory formation. PAPERFLICK: ..
  5. Welker N, Habig J, Bass B. Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. RNA. 2007;13:1090-102 pubmed
    ..However, all three data sets are enriched in genes important for innate immunity and, specifically, show increased expression of innate immunity genes. ..
  6. Iatsenko I, Sinha A, Rödelsperger C, Sommer R. New role for DCR-1/dicer in Caenorhabditis elegans innate immunity against the highly virulent bacterium Bacillus thuringiensis DB27. Infect Immun. 2013;81:3942-57 pubmed publisher
    ..Taken together, these results uncover a previously unknown role for DCR-1/Dicer in C. elegans antibacterial immunity that is largely associated with miRNA processing. ..
  7. Mori M, Raghavan P, Thomou T, Boucher J, Robida Stubbs S, Macotela Y, et al. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 2012;16:336-47 pubmed publisher
    ..Thus, regulation of miRNA processing in adipose-related tissues plays an important role in longevity and the ability of an organism to respond to environmental stress and age-related disease...
  8. Vasale J, Gu W, Thivierge C, Batista P, Claycomb J, Youngman E, et al. Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. Proc Natl Acad Sci U S A. 2010;107:3582-7 pubmed publisher
    ..ERGO-1 targets exhibit a nonrandom distribution in the genome and appear to include many gene duplications, suggesting that this pathway may control overexpression resulting from gene expansion. ..
  9. Grishok A, Pasquinelli A, Conte D, Li N, Parrish S, Ha I, et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001;106:23-34 pubmed
    ..Our findings suggest that a common processing machinery generates guide RNAs that mediate both RNAi and endogenous gene regulation. ..

More Information


  1. Thivierge C, Makil N, Flamand M, Vasale J, Mello C, Wohlschlegel J, et al. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011;19:90-7 pubmed publisher
    ..Our results implicate tudor proteins in the recruitment of RdRP complexes to specific steps within DCR-1-dependent and DCR-1-independent endo-RNAi pathways. ..
  2. Tabara H, Yigit E, Siomi H, Mello C. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 2002;109:861-71 pubmed
    ..Our findings suggest a model in which RDE-4 and RDE-1 function together to detect and retain foreign dsRNA and to present this dsRNA to DCR-1 for processing. ..
  3. Mackay C, Wang J, Kurt Jones E. Dicer's role as an antiviral: still an enigma. Curr Opin Immunol. 2014;26:49-55 pubmed publisher
    ..Notably, such antiviral activity has not yet been clearly demonstrated in higher organisms such as mammals. Here, we review the evidence for Dicer as an innate antiviral across species...
  4. Beshore E, McEwen T, Jud M, Marshall J, Schisa J, Bennett K. C. elegans Dicer interacts with the P-granule component GLH-1 and both regulate germline RNPs. Dev Biol. 2011;350:370-81 pubmed publisher
    ..We predict that the GLH-1/DCR-1 complex may function in the transport, deposition, or regulation of maternally-transcribed mRNAs and their associated miRNAs. ..
  5. Welker N, Maity T, Ye X, Aruscavage P, Krauchuk A, Liu Q, et al. Dicer's helicase domain discriminates dsRNA termini to promote an altered reaction mode. Mol Cell. 2011;41:589-99 pubmed publisher
  6. Nakagawa A, Shi Y, Kage Nakadai E, Mitani S, Xue D. Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science. 2010;328:327-34 pubmed publisher
    ..DCR-1 functions in fragmenting chromosomal DNA during apoptosis, in addition to processing of small RNAs, and undergoes a protease-mediated conversion from a ribonuclease to a deoxyribonuclease. ..
  7. Ge X, Zhao X, Nakagawa A, Gong X, Skeen Gaar R, Shi Y, et al. A novel mechanism underlies caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease during apoptosis. Cell Res. 2014;24:218-32 pubmed publisher
    ..We suggest the possibility that this phenomenon may be extrapolated to other ribonucleases. ..
  8. Welker N, Pavelec D, Nix D, Duchaine T, Kennedy S, Bass B. Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs. RNA. 2010;16:893-903 pubmed publisher
  9. Schott D, Cureton D, Whelan S, Hunter C. An antiviral role for the RNA interference machinery in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2005;102:18420-4 pubmed
    ..Our observation that multiple genes required for RNAi are also required for resistance to vesicular stomatitis virus suggests that the RNAi machinery functions in resistance to viruses in nature. ..
  10. Denli A, Tops B, Plasterk R, Ketting R, Hannon G. Processing of primary microRNAs by the Microprocessor complex. Nature. 2004;432:231-5 pubmed
    ..Considered together, these results indicate a role for Pasha in miRNA maturation and miRNA-mediated gene regulation. ..
  11. Rybak Wolf A, Jens M, Murakawa Y, Herzog M, Landthaler M, Rajewsky N. A variety of dicer substrates in human and C. elegans. Cell. 2014;159:1153-1167 pubmed publisher
    ..Together, we provide the first transcriptome-wide map of Dicer targets and suggest conserved binding modes and functions outside of the miRNA pathway. ..
  12. Knight S, Bass B. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science. 2001;293:2269-71 pubmed
    ..Mutant animals have germ line defects that lead to sterility, suggesting that cleavage of dsRNA to short pieces is a requisite event in normal development. ..
  13. Pavelec D, Lachowiec J, Duchaine T, Smith H, Kennedy S. Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans. Genetics. 2009;183:1283-95 pubmed publisher
  14. Chatterjee S, Grosshans H. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature. 2009;461:546-9 pubmed publisher
    ..This pathway might represent a potential target for therapeutic intervention on miRNA expression. ..
  15. Duchaine T, Wohlschlegel J, Kennedy S, Bei Y, Conte D, Pang K, et al. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006;124:343-54 pubmed
    ..Our findings provide a first glimpse at the complex biochemical niche of Dicer and suggest that competition exists between DCR-1-mediated small-RNA pathways. ..