Gene Symbol: dapk-1
Description: DAP (Death-Associated Protein) Kinase homolog;Death-associated protein kinase dapk-1
Alias: DAP (Death-Associated Protein) Kinase homolog;Death-associated protein kinase dapk-1
Species: Caenorhabditis elegans

Top Publications

  1. Kang C, Avery L. Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis. FEBS J. 2010;277:66-73 pubmed publisher
  2. Tong A, Lynn G, Ngo V, Wong D, Moseley S, Ewbank J, et al. Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase. Proc Natl Acad Sci U S A. 2009;106:1457-61 pubmed publisher
    ..Our results reveal a previously undescribed function for the DAPK tumor suppressor family in regulation of epithelial damage responses. ..
  3. An J, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, et al. Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A. 2005;102:16275-80 pubmed
    ..We conclude that (i) GSK-3 inhibits SKN-1 activity in the intestine, (ii) the phase II response integrates multiple regulatory signals, and (iii), by inhibiting this response, GSK-3 may influence redox conditions. ..
  4. Xu S, Chisholm A. A G?q-Ca²? signaling pathway promotes actin-mediated epidermal wound closure in C. elegans. Curr Biol. 2011;21:1960-7 pubmed publisher
    ..elegans triggers a Ca(2+)-dependent signaling cascade that promotes wound closure, in parallel to the innate immune response to damage. Wound closure requires actin polymerization and is negatively regulated by nonmuscle myosin. ..
  5. Chuang M, Hsiao T, Tong A, Xu S, Chisholm A. DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair. elife. 2016;5: pubmed publisher
    ..Our results uncover an unexpected interdependence of DAPK-1 and the microtubule cytoskeleton in maintenance of epidermal integrity. ..
  6. Chen F, Chisholm A, Jin Y. Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development. Development. 2017;144:698-707 pubmed publisher
    ..Our data reveal that tissue and stage-specific expression of ankyrin isoforms relies on differential activity of positive and negative regulators of alternative polyadenylation. ..
  7. Del Rosario J, Feldmann K, Ahmed T, Amjad U, Ko B, An J, et al. Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity. BMC Neurosci. 2015;16:25 pubmed publisher
    ..Our studies highlight the prominence of DAPK and Pin1/PINN-1 as conserved mediators of cell death processes in diverse scenarios of neurodegeneration. ..