Gene Symbol: daf-8
Description: Dwarfin sma
Alias: Dwarfin sma
Species: Caenorhabditis elegans

Top Publications

  1. Shaw W, Luo S, Landis J, Ashraf J, Murphy C. The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 2007;17:1635-45 pubmed
    ..Together, our results suggest there are TGF-beta-specific downstream targets and functions, but that the TGF-beta and IIS pathways might be more tightly linked in the regulation of longevity than has been previously appreciated. ..
  2. Park D, Estevez A, Riddle D. Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans. Development. 2010;137:477-85 pubmed publisher
    ..In the adult, DAF-8 downregulates lag-2 expression in the distal tip cells, thus promoting germ line meiosis. This function does not involve DAF-3, thereby avoiding the feedback loop that functions in the dauer switch. ..
  3. Vowels J, Thomas J. Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics. 1992;130:105-23 pubmed
    ..These results suggest that daf-11 is directly involved in chemosensory transduction essential for dauer formation, while the other Daf-c genes play roles downstream of the chemosensory step. ..
  4. Golden J, Riddle D. A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A. 1984;81:819-23 pubmed
    ..These mutations appear to indirectly result in a ts phenotype by enhancing the expression of a wild-type ts developmental process. ..
  5. Schackwitz W, Inoue T, Thomas J. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron. 1996;17:719-28 pubmed
    ..Mutations in the second genetic pathway activate dauer formation in an ASJ-dependent manner. Thus, the genetic redundancy in this process is reflected at the neuronal level. ..
  6. Inoue T, Thomas J. Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation. Dev Biol. 2000;217:192-204 pubmed
    ..Instead, these experiments suggest the nervous system as a target of DAF-7 signaling and that the nervous system in turn regulates dauer formation by other tissues. ..
  7. Thatcher J, Haun C, Okkema P. The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development. 1999;126:97-107 pubmed
    ..We have examined expression of this gfp reporter in dauer larvae and have observed no daf-3-dependent repression of C activity. These results suggest daf-3 directly regulates pharyngeal gene expression during non-dauer development. ..
  8. Reddy K, Andersen E, Kruglyak L, Kim D. A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science. 2009;323:382-4 pubmed publisher
    ..For C. elegans, bacteria represent food but also a potential source of infection. Our data underscore the importance of behavioral responses to oxygen levels in finding an optimal balance between these potentially conflicting cues. ..
  9. Park D, Jones K, Lee H, Snutch T, Taubert S, Riddle D. Repression of a potassium channel by nuclear hormone receptor and TGF-? signaling modulates insulin signaling in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002519 pubmed publisher
    ..elegans. NHR-69 and DAF-8 dependent regulation of exp-2 and DAF-28 also provides a novel molecular mechanism that contributes to the previously recognized link between insulin and TGF-? signaling in C. elegans. ..

More Information


  1. Meisel J, Panda O, Mahanti P, Schroeder F, Kim D. Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell. 2014;159:267-80 pubmed publisher