Gene Symbol: daf-6
Description: hypothetical protein
Species: Caenorhabditis elegans
Perkins L, Hedgecock E, Thomson J, Culotti J. Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev Biol. 1986;117:456-87 pubmed
..The cat-6 (e1861) mutation disrupts the tubular bodies of the CEP mechanocilia. A cryophilic thermotaxis mutant, ttx-1 (p767), lacks fingers on the AFD dendrite, suggesting this neuron is thermosensory. ..
Perens E, Shaham S. C. elegans daf-6 encodes a patched-related protein required for lumen formation. Dev Cell. 2005;8:893-906 pubmed
..We propose that amphid lumen morphogenesis is coordinated by neuron-derived cues and a DAF-6/CHE-14 system that regulates vesicle dynamics during tubulogenesis...
Starich T, Herman R, Kari C, Yeh W, Schackwitz W, Schuyler M, et al
. Mutations affecting the chemosensory neurons of Caenorhabditis elegans. Genetics. 1995;139:171-88 pubmed
..We have assigned 20 mutations to 13 new genes, called dyf-1 through dyf-13. We expect that the genes represented by dye-filing defective mutants are important for the differentiation of amphid and phasmid chemosensilla. ..
Golden J, Riddle D. A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A. 1984;81:819-23 pubmed
..These mutations appear to indirectly result in a ts phenotype by enhancing the expression of a wild-type ts developmental process. ..
Moussaif M, Sze J. Intraflagellar transport/Hedgehog-related signaling components couple sensory cilium morphology and serotonin biosynthesis in Caenorhabditis elegans. J Neurosci. 2009;29:4065-75 pubmed publisher
..elegans under stress and stress recovery...
Oikonomou G, Perens E, Lu Y, Watanabe S, Jorgensen E, Shaham S. Opposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegans. PLoS Biol. 2011;9:e1001121 pubmed publisher
..Our results suggest that the opposing daf-6 and lit-1 glial pathways act together to control sensory compartment size. ..
Lin K, Hsin H, Libina N, Kenyon C. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet. 2001;28:139-45 pubmed
..Together these findings reveal unexpected complexity in the DAF-16-dependent pathways that regulate aging. ..