daf 4


Gene Symbol: daf 4
Description: Cell surface receptor daf-4;Receptor protein serine/threonine kinase;Serine/threonine-protein kinase receptor
Alias: Cell surface receptor daf-4;Receptor protein serine/threonine kinase;Serine/threonine-protein kinase receptor
Species: Caenorhabditis elegans

Top Publications

  1. Patterson G, Koweek A, Wong A, Liu Y, Ruvkun G. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 1997;11:2679-90 pubmed
    ..Therefore, daf-3 is unique in that it is antagonized, rather than activated, by a TGF-beta pathway. ..
  2. Greer E, Perez C, Van Gilst M, Lee B, Ashrafi K. Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab. 2008;8:118-31 pubmed publisher
    ..Thus, neural perception of adverse environmental conditions can promote fat accumulation without a concomitant increase in feeding rate. ..
  3. Morita K, Chow K, Ueno N. Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family. Development. 1999;126:1337-47 pubmed
    ..Our results show that cet-1 controls diverse biological processes during C. elegans development probably through different target genes. ..
  4. Vowels J, Thomas J. Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics. 1992;130:105-23 pubmed
    ..These results suggest that daf-11 is directly involved in chemosensory transduction essential for dauer formation, while the other Daf-c genes play roles downstream of the chemosensory step. ..
  5. Zugasti O, Ewbank J. Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermis. Nat Immunol. 2009;10:249-56 pubmed publisher
  6. Gunther C, Riddle D. Alternative polyadenylation results in a truncated daf-4 BMP receptor that antagonizes DAF-7-mediated development in Caenorhabditis elegans. J Biol Chem. 2004;279:39555-64 pubmed
    ..0 kb transcript can function as an antagonist of full-length DAF-4 signaling. Alternative processing of type II receptor transcripts to generate an antagonist is a novel mechanism for negative regulation of a TGF-beta signaling pathway. ..
  7. Golden J, Riddle D. A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A. 1984;81:819-23 pubmed
    ..These mutations appear to indirectly result in a ts phenotype by enhancing the expression of a wild-type ts developmental process. ..
  8. You Y, Kim J, Raizen D, Avery L. Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety. Cell Metab. 2008;7:249-57 pubmed publisher
    ..The EGL-4 cGMP-dependent protein kinase functions downstream of insulin and TGF-beta in sensory neurons including ASI to control quiescence in response to food intake. ..
  9. Perlman R, Schiemann W, Brooks M, Lodish H, Weinberg R. TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol. 2001;3:708-14 pubmed
    ..Our findings associate Daxx directly with the TGF-beta apoptotic-signalling pathway, and make a biochemical connection between the receptors for TGF-beta and the apoptotic machinery. ..

More Information


  1. Ramakrishnan K, Ray P, Okkema P. CEH-28 activates dbl-1 expression and TGF-? signaling in the C. elegans M4 neuron. Dev Biol. 2014;390:149-59 pubmed publisher
    ..Together these results identify a novel neuroendocrine function for M4 and provide evidence for an R-Smad-independent mechanism for DBL-1 signaling in C. elegans...
  2. Thatcher J, Haun C, Okkema P. The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development. 1999;126:97-107 pubmed
    ..We have examined expression of this gfp reporter in dauer larvae and have observed no daf-3-dependent repression of C activity. These results suggest daf-3 directly regulates pharyngeal gene expression during non-dauer development. ..
  3. Estevez M, Attisano L, Wrana J, Albert P, Massague J, Riddle D. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature. 1993;365:644-9 pubmed
    ..When expressed in monkey COS cells, the daf-4 receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family. ..
  4. Malone E, Thomas J. A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans. Genetics. 1994;136:879-86 pubmed
    ..This finding strengthens the hypothesis that a branched genetic pathway controls dauer formation. ..
  5. Savage Dunn C, Maduzia L, Zimmerman C, Roberts A, Cohen S, Tokarz R, et al. Genetic screen for small body size mutants in C. elegans reveals many TGFbeta pathway components. Genesis. 2003;35:239-47 pubmed
    ..Because of the conservation of TGFbeta signaling pathways, homologs of these genes may be involved in tissue specificity and/or crosstalk of TGFbeta pathways in other animals. ..
  6. Shaw W, Luo S, Landis J, Ashraf J, Murphy C. The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 2007;17:1635-45 pubmed
    ..Together, our results suggest there are TGF-beta-specific downstream targets and functions, but that the TGF-beta and IIS pathways might be more tightly linked in the regulation of longevity than has been previously appreciated. ..
  7. Inoue T, Thomas J. Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation. Dev Biol. 2000;217:192-204 pubmed
    ..Instead, these experiments suggest the nervous system as a target of DAF-7 signaling and that the nervous system in turn regulates dauer formation by other tissues. ..
  8. Gunther C, Georgi L, Riddle D. A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development. Development. 2000;127:3337-47 pubmed
    ..Signaling from a strong DAF-1/DAF-4 receptor complex or a weaker DAF-1 receptor alone may provide larvae with more precise control of the dauer/nondauer decision in a range of environmental conditions. ..
  9. Inoue T, Ailion M, Poon S, Kim H, Thomas J, Sternberg P. Genetic analysis of dauer formation in Caenorhabditis briggsae. Genetics. 2007;177:809-18 pubmed
    ..elegans. In contrast, C. briggsae, which is capable of growth at higher temperatures than C. elegans, lacks this response. ..
  10. Liu Z, Shi H, Szymczak L, Aydin T, Yun S, Constas K, et al. Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids. PLoS Genet. 2015;11:e1005221 pubmed publisher