Gene Symbol: daf-3
Description: Dwarfin sma;hypothetical protein
Alias: Dwarfin sma;hypothetical protein
Species: Caenorhabditis elegans
Products:     daf-3

Top Publications

  1. Riddle D, Swanson M, Albert P. Interacting genes in nematode dauer larva formation. Nature. 1981;290:668-71 pubmed
    ..Mutant genes controlling the ability to form dauer larvae interact in a way which allows them to be ordered in a pathway. Mutant phenotypes suggest that the pathway corresponds to neural processing of environmental stimuli. ..
  2. Patterson G, Koweek A, Wong A, Liu Y, Ruvkun G. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 1997;11:2679-90 pubmed
    ..Therefore, daf-3 is unique in that it is antagonized, rather than activated, by a TGF-beta pathway. ..
  3. Greene J, Brown M, Dobosiewicz M, Ishida I, Macosko E, Zhang X, et al. Balancing selection shapes density-dependent foraging behaviour. Nature. 2016;539:254-258 pubmed publisher
    ..These results suggest that balancing selection at the srx-43 locus generates alternative density-dependent behaviours, fulfilling a prediction of foraging game theory. ..
  4. Golden J, Riddle D. A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A. 1984;81:819-23 pubmed
    ..These mutations appear to indirectly result in a ts phenotype by enhancing the expression of a wild-type ts developmental process. ..
  5. Thatcher J, Haun C, Okkema P. The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development. 1999;126:97-107 pubmed
    ..We have examined expression of this gfp reporter in dauer larvae and have observed no daf-3-dependent repression of C activity. These results suggest daf-3 directly regulates pharyngeal gene expression during non-dauer development. ..
  6. Shaw W, Luo S, Landis J, Ashraf J, Murphy C. The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 2007;17:1635-45 pubmed
    ..Together, our results suggest there are TGF-beta-specific downstream targets and functions, but that the TGF-beta and IIS pathways might be more tightly linked in the regulation of longevity than has been previously appreciated. ..
  7. Greer E, Perez C, Van Gilst M, Lee B, Ashrafi K. Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab. 2008;8:118-31 pubmed publisher
    ..Thus, neural perception of adverse environmental conditions can promote fat accumulation without a concomitant increase in feeding rate. ..
  8. Jensen V, Bialas N, Bishop Hurley S, Molday L, Kida K, Nguyen P, et al. Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. PLoS Genet. 2010;6:e1001199 pubmed publisher
    ..In summary, we have discovered a novel ciliary protein that plays an important role in cGMP signaling by localizing a guanylyl cyclase to the sensory organelle. ..
  9. Meisel J, Panda O, Mahanti P, Schroeder F, Kim D. Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell. 2014;159:267-80 pubmed publisher

More Information


  1. Inoue T, Ailion M, Poon S, Kim H, Thomas J, Sternberg P. Genetic analysis of dauer formation in Caenorhabditis briggsae. Genetics. 2007;177:809-18 pubmed
    ..elegans. In contrast, C. briggsae, which is capable of growth at higher temperatures than C. elegans, lacks this response. ..