Gene Symbol: daf-18
Description: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
Alias: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
Species: Caenorhabditis elegans

Top Publications

  1. Lin K, Hsin H, Libina N, Kenyon C. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet. 2001;28:139-45 pubmed
    ..Together these findings reveal unexpected complexity in the DAF-16-dependent pathways that regulate aging. ..
  2. Masse I, Molin L, Billaud M, Solari F. Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18. Dev Biol. 2005;286:91-101 pubmed
    ..Overall, our data strongly suggest that several tissues act as signaling centers to mediate DAF-18 function and that DAF-18 could act outside the canonical DAF-2/DAF-16 pathway to regulate dauer and lifespan. ..
  3. Brisbin S, Liu J, Boudreau J, Peng J, Evangelista M, Chin Sang I. A role for C. elegans Eph RTK signaling in PTEN regulation. Dev Cell. 2009;17:459-69 pubmed publisher
    ..Possible implications for human cancers are discussed, based on the idea that mutually inhibitory interactions between PTEN and Eph RTKs may be conserved. ..
  4. Christensen R, de la Torre Ubieta L, Bonni A, COLON RAMOS D. A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development. Development. 2011;138:5257-67 pubmed publisher
    ..These data provide a novel mechanism by which the conserved PI3K signaling pathway regulates neuronal cell morphology during development through FOXO. ..
  5. Padmanabhan S, Mukhopadhyay A, Narasimhan S, Tesz G, Czech M, Tissenbaum H. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell. 2009;136:939-51 pubmed publisher
    ..This study reveals a conserved role for the B56 regulatory subunit in regulating insulin signaling through AKT dephosphorylation, thereby having widespread implications in cancer and diabetes research. ..
  6. Narbonne P, Maddox P, Labbé J. DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans. Development. 2015;142:4230-41 pubmed publisher
    ..Thus, during adulthood, stem cells can differentially respond within tissues to otherwise equal insulin/IGF-1 signalling inputs, according to the needs for production of their immediate terminally differentiated progeny. ..
  7. Tomioka M, Adachi T, Suzuki H, Kunitomo H, Schafer W, Iino Y. The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans. Neuron. 2006;51:613-25 pubmed
    ..These results suggest that INS-1 secreted from AIA interneurons provides feedback to ASER to generate plasticity of chemotaxis. ..
  8. Armstrong K, Chamberlin H. Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6. Mol Genet Genomics. 2010;283:73-87 pubmed publisher
    ..This work suggests that a role for POU-III factors in renal organs is to coordinate the expression of a set of functionally related genes. ..
  9. Golden J, Riddle D. A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A. 1984;81:819-23 pubmed
    ..These mutations appear to indirectly result in a ts phenotype by enhancing the expression of a wild-type ts developmental process. ..

More Information


  1. Khanna A, Johnson D, Curran S. Physiological roles for mafr-1 in reproduction and lipid homeostasis. Cell Rep. 2014;9:2180-91 pubmed publisher
    ..Our results reveal physiological roles for mafr-1 in regulating organismal lipid homeostasis, which ensure reproductive success. ..
  2. Wolf T, Qi W, Schindler V, Runkel E, Baumeister R. Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background. Exp Gerontol. 2014;56:114-22 pubmed publisher
  3. Nakdimon I, Walser M, Fröhli E, Hajnal A. PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development. PLoS Genet. 2012;8:e1002881 pubmed publisher
    ..Thus, mutations in the PTEN tumor suppressor gene may result in the simultaneous hyper-activation of two oncogenic signaling pathways. ..
  4. Jiu Y, Yue Y, Yang S, Liu L, Yu J, Wu Z, et al. Insulin-like signaling pathway functions in integrative response to an olfactory and a gustatory stimuli in Caenorhabditis elegans. Protein Cell. 2010;1:75-81 pubmed publisher
    ..These results suggest that the insulin-like signaling pathway constitutes an essential component for sensory integration and decision-making behavior plasticity. ..
  5. Larsen P, Albert P, Riddle D. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics. 1995;139:1567-83 pubmed
    ..This synergistic effect, which does not equivalently extend the fertile period, is the largest genetic extension of life span yet observed in a metazoan. ..
  6. Adachi T, Kunitomo H, Tomioka M, Ohno H, Okochi Y, Mori I, et al. Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics. 2010;186:1309-19 pubmed publisher
    ..A putative salt receptor GCY-22 guanylyl cyclase is required in ASER for both salt attraction and avoidance. Our results suggest that ASEL and ASER use distinct molecular mechanisms to regulate salt chemotaxis plasticity. ..
  7. Vowels J, Thomas J. Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics. 1992;130:105-23 pubmed
    ..These results suggest that daf-11 is directly involved in chemosensory transduction essential for dauer formation, while the other Daf-c genes play roles downstream of the chemosensory step. ..
  8. Narbonne P, Maddox P, Labbé J. DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation. PLoS Genet. 2017;13:e1006738 pubmed publisher
    ..As all components are conserved, similar signalling cascades may regulate stem cell activities in other organisms and be widely implicated in cancer. ..
  9. Mouchiroud L, Molin L, Kasturi P, Triba M, Dumas M, Wilson M, et al. Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell. 2011;10:39-54 pubmed publisher
    ..These findings suggest that inhibition of this transporter homolog in mammals might also promote a DR response. ..
  10. Mihaylova V, Borland C, Manjarrez L, Stern M, Sun H. The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc Natl Acad Sci U S A. 1999;96:7427-32 pubmed
    ..Furthermore, our studies have uncovered a longevity-promoting activity of the PTEN homolog in C. elegans. ..
  11. Rouault J, Kuwabara P, Sinilnikova O, Duret L, Thierry Mieg D, Billaud M. Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN. Curr Biol. 1999;9:329-32 pubmed
    ..These data further support the notion that mutations of PTEN contribute to the development of human neoplasia through an aberrant activation of the PI 3-kinase signalling cascade. ..