Gene Symbol: daf-11
Description: Receptor-type guanylate cyclase daf-11;hypothetical protein
Alias: Receptor-type guanylate cyclase daf-11;hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Vowels J, Thomas J. Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans. Genetics. 1994;138:303-16 pubmed
    ..We propose that daf-11 and daf-21 mediate sensory transduction for both volatile and non-volatile compounds in specific amphid neurons. ..
  2. Birnby D, Link E, Vowels J, Tian H, Colacurcio P, Thomas J. A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans. Genetics. 2000;155:85-104 pubmed
    ..These results demonstrate that cGMP is a prominent second messenger in C. elegans chemosensory transduction and suggest a previously unknown role for Hsp90 in regulating cGMP levels. ..
  3. Hahm J, Kim S, Paik Y. Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans. Aging Cell. 2009;8:473-83 pubmed publisher
    ..Our findings provide not only a new mechanism of cGMP-mediated induction of longevity in adult C. elegans but also a possible therapeutic strategy for neuronal disease, which has been likened to brain diabetes. ..
  4. Liu J, Ward A, Gao J, Dong Y, Nishio N, Inada H, et al. C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat Neurosci. 2010;13:715-22 pubmed publisher
    ..Our results identify a phototransduction cascade in C. elegans and implicate the function of a 'taste receptor' in phototransduction. ..
  5. Murakami M, Koga M, Ohshima Y. DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11. Mech Dev. 2001;109:27-35 pubmed
    ..Expression of daf-11 cDNA by cell specific promoters suggests that daf-11 acts cell autonomously in ASI chemosensory neurons for daf-7 expression. ..
  6. Coburn C, Mori I, Ohshima Y, Bargmann C. A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure. Development. 1998;125:249-58 pubmed
    ..daf-11 regulates a developmental process called dauer larva formation that is controlled by sensory stimuli, and tax-2 and tax-4 can either stimulate or inhibit dauer larva formation in different contexts. ..
  7. Vowels J, Thomas J. Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics. 1992;130:105-23 pubmed
    ..These results suggest that daf-11 is directly involved in chemosensory transduction essential for dauer formation, while the other Daf-c genes play roles downstream of the chemosensory step. ..
  8. Golden J, Riddle D. A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A. 1984;81:819-23 pubmed
    ..These mutations appear to indirectly result in a ts phenotype by enhancing the expression of a wild-type ts developmental process. ..
  9. Schackwitz W, Inoue T, Thomas J. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron. 1996;17:719-28 pubmed
    ..Mutations in the second genetic pathway activate dauer formation in an ASJ-dependent manner. Thus, the genetic redundancy in this process is reflected at the neuronal level. ..

More Information


  1. Inoue T, Thomas J. Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation. Dev Biol. 2000;217:192-204 pubmed
    ..Instead, these experiments suggest the nervous system as a target of DAF-7 signaling and that the nervous system in turn regulates dauer formation by other tissues. ..
  2. Torayama I, Ishihara T, Katsura I. Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone. J Neurosci. 2007;27:741-50 pubmed
  3. Jensen V, Bialas N, Bishop Hurley S, Molday L, Kida K, Nguyen P, et al. Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. PLoS Genet. 2010;6:e1001199 pubmed publisher
    ..In summary, we have discovered a novel ciliary protein that plays an important role in cGMP signaling by localizing a guanylyl cyclase to the sensory organelle. ..
  4. Beckert U, Aw W, Burhenne H, Försterling L, Kaever V, Timmons L, et al. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]. PLoS ONE. 2013;8:e72569 pubmed publisher
    ..elegans using highly specific HPLC-coupled tandem mass-spectrometry and behavioral assays. Here, we show that the relation between cGMP and survival is more complex than previously appreciated. ..
  5. Meisel J, Panda O, Mahanti P, Schroeder F, Kim D. Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell. 2014;159:267-80 pubmed publisher
  6. Fujiwara M, Hino T, Miyamoto R, Inada H, Mori I, Koga M, et al. The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans. Genetics. 2015;201:1497-510 pubmed publisher
    ..The large number of guanylyl cyclases encoded in the C. elegans genome suggests that EGL-4 exerts pleiotropic effects by partnering with different guanylyl cyclases for different downstream functions. ..