Gene Symbol: dab-1
Description: DAB (Drosophila disabled) homolog
Alias: DAB (Drosophila disabled) homolog
Species: Caenorhabditis elegans

Top Publications

  1. Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed
    ..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
  2. Kamikura D, Cooper J. Clathrin interaction and subcellular localization of Ce-DAB-1, an adaptor for protein secretion in Caenorhabditis elegans. Traffic. 2006;7:324-36 pubmed
  3. Govindan J, Cheng H, Harris J, Greenstein D. Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans. Curr Biol. 2006;16:1257-68 pubmed
    ..elegans, highlighting contrasts and parallels between MSP signaling in C. elegans and luteinizing hormone signaling in mammals. ..
  4. Wang W, Bouhours M, Gracheva E, Liao E, Xu K, Sengar A, et al. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Traffic. 2008;9:742-54 pubmed publisher
    ..These results show for the first time that intersectin and Eps15 proteins function in the same genetic pathway, and appear to function synergistically with the clathrin-coat-associated sorting protein, Disabled, for viability. ..
  5. Suzuki Y, Han M. Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development. Genes Dev. 2006;20:423-8 pubmed
    ..We provide evidence that daf-18 elicits some functions independent of the downstream gene daf-16...
  6. Holmes A, Flett A, Coudreuse D, Korswagen H, Pettitt J. C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex. J Cell Sci. 2007;120:2741-51 pubmed
  7. Yochem J, Lažetić V, Bell L, Chen L, FAY D. C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting. Dev Biol. 2015;398:255-66 pubmed publisher
    ..Our findings provide the first genetic and in vivo evidence for a role of NEK family members in endocytosis, which may be evolutionarily conserved. ..