Gene Symbol: cye-1
Description: G1/S-specific cyclin-E
Alias: G1/S-specific cyclin-E
Species: Caenorhabditis elegans
Products:     cye-1

Top Publications

  1. Saito R, Perreault A, Peach B, Satterlee J, van den Heuvel S. The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans. Nat Cell Biol. 2004;6:777-83 pubmed
    ..Our data support a model in which CDC-14 promotes a hypophosphorylated and stable form of CKI-1 required for developmentally programmed cell-cycle arrest. ..
  2. Tilmann C, Kimble J. Cyclin D regulation of a sexually dimorphic asymmetric cell division. Dev Cell. 2005;9:489-99 pubmed
    ..We propose that cyclin D and other canonical regulators of the G1/S transition coordinate key regulators of axis formation and sex determination with cell cycle progression to achieve the sexually dimorphic SGP asymmetric division. ..
  3. Fujita M, Takeshita H, Sawa H. Cyclin E and CDK2 repress the terminal differentiation of quiescent cells after asymmetric division in C. elegans. PLoS ONE. 2007;2:e407 pubmed
    ..Our results suggest that the balance between the levels of CKI and cyclin E determines three distinct cell states: terminally differentiated, quiescent and uncommitted, and proliferating. ..
  4. Fay D, Han M. Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development. Development. 2000;127:4049-60 pubmed
    ..By analyzing cul-1 mutants, we further demonstrate that vulval cell terminal differentiation can be uncoupled from associated changes in vulval cell division planes. ..
  5. Brodigan T, Liu J, Park M, Kipreos E, Krause M. Cyclin E expression during development in Caenorhabditis elegans. Dev Biol. 2003;254:102-15 pubmed
    ..Our analysis of a new cye-1 deletion allele confirms and extends previous studies of two point mutations in the gene. ..
  6. Biedermann B, Wright J, Senften M, Kalchhauser I, Sarathy G, Lee M, et al. Translational repression of cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis. Dev Cell. 2009;17:355-64 pubmed publisher
  7. Fox P, Vought V, Hanazawa M, Lee M, Maine E, Schedl T. Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline. Development. 2011;138:2223-34 pubmed publisher
    ..Furthermore, we find that GLP-1 signaling regulates a third pathway, in addition to the GLD-1 and GLD-2 pathways and also independent of CYE-1/CDK-2, to promote the proliferative fate/inhibit meiotic entry. ..
  8. Simon F, Fichelson P, Gho M, Audibert A. Notch and Prospero repress proliferation following cyclin E overexpression in the Drosophila bristle lineage. PLoS Genet. 2009;5:e1000594 pubmed publisher
    ..Our results demonstrate that the terminal quiescent state and differentiation are regulated by two parallel mechanisms acting simultaneously on fate acquisition and cell cycle progression. ..
  9. Kostić I, Roy R. Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans. Development. 2002;129:2155-65 pubmed
    ..In addition, we showed that the cdc-25.1(gf) requires cyclin E. The extra cell division defect was shown to be restricted to the E lineage and the E fate is necessary and sufficient to sensitize cells to this mutation. ..

More Information


  1. Cowan C, Hyman A. Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos. Nat Cell Biol. 2006;8:1441-7 pubmed
    ..elegans and Drosophila. Here, we suggest a possible mechanism for cyclin E-Cdk2-dependent differentiation: the establishment of cortical polarity by the centrosome. ..
  2. Jeong J, Verheyden J, Kimble J. Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. PLoS Genet. 2011;7:e1001348 pubmed publisher
    ..Therefore, CYE-1/CDK-2 emerges as a critical regulator of stem cell maintenance. We suggest that cyclin E and Cdk-2 may be used broadly to control developmental regulators. ..
  3. Korzelius J, The I, Ruijtenberg S, Prinsen M, Portegijs V, Middelkoop T, et al. Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. PLoS Genet. 2011;7:e1002362 pubmed publisher