Gene Symbol: cwn-1
Description: Protein Wnt-1
Alias: Protein Wnt-1
Species: Caenorhabditis elegans

Top Publications

  1. Pan C, Howell J, Clark S, Hilliard M, Cordes S, Bargmann C, et al. Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Dev Cell. 2006;10:367-77 pubmed
    ..Our results indicate that Wnts play a key role in A/P guidance in C. elegans and employ distinct mechanisms to regulate different migrations. ..
  2. Herman M, Vassilieva L, Horvitz H, Shaw J, Herman R. The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously. Cell. 1995;83:101-10 pubmed
    ..Our mosaic analysis indicates that lin-44 acts cell nonautonomously. We propose that LIN-44 protein is secreted by tail hypodermal cells and affects the polarity of asymmetric cell divisions that occur more anteriorly in the tail. ..
  3. Gleason J, Szyleyko E, Eisenmann D. Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development. Dev Biol. 2006;298:442-57 pubmed
    ..p lineage. Here, too, we found that four of five Wnt receptors can influence P7.p orientation, suggesting that a surprising amount of functional redundancy exists in Wnt signaling during C. elegans vulval induction...
  4. Shackleford G, Shivakumar S, Shiue L, Mason J, Kenyon C, Varmus H. Two wnt genes in Caenorhabditis elegans. Oncogene. 1993;8:1857-64 pubmed
    ..5 kb in length. Both RNAs are detectable in all larval forms and adults, but they are most abundant at the embryonic stage. Ce-wnt-1 is localized to the left arm of chromosome II and Ce-wnt-2 maps to a cluster of genes on chromosome IV. ..
  5. Baugh L, Wen J, Hill A, Slonim D, Brown E, Hunter C. Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. Genome Biol. 2005;6:R45 pubmed
    ..Genetic interactions within a homologous set of genes involved in vertebrate myogenesis indicate broad conservation of the muscle module and suggest that other genetic modules identified in C. elegans will be conserved. ..
  6. Green J, Inoue T, Sternberg P. The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development. 2007;134:4053-62 pubmed
    ..A sequestration model is supported by our findings that the CAM-1 ECD binds to several Wnts in vitro. These results demonstrate how ROR proteins help to refine the spatial pattern of Wnt activity in a complex multicellular environment...
  7. Zhang H, Skop A, White J. Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos. J Cell Sci. 2008;121:155-61 pubmed publisher
    ..By RNAi of a weak dnc-1(ts) allele, we showed that dynactin activity was required at least for EMS spindle rotational alignment. ..
  8. Zinovyeva A, Yamamoto Y, Sawa H, Forrester W. Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development. Genetics. 2008;179:1357-71 pubmed publisher
    ..Finally, we find striking differences between the phenotypes of the Wnt quintuple and Frizzled quadruple mutants. ..
  9. Hingwing K, Lee S, Nykilchuk L, Walston T, Hardin J, Hawkins N. CWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway. Dev Biol. 2009;328:245-56 pubmed publisher
    ..In particular, DSH-2 function is necessary for the correct production of the embryonic ventral cord motor neurons. This study demonstrates a role for DSH-2 and Wnt signaling in neuronal specification during C. elegans embryogenesis. ..

More Information


  1. Yamamoto Y, Takeshita H, Sawa H. Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells. PLoS Genet. 2011;7:e1002308 pubmed publisher
    ..Our results provide a paradigm for understanding how cell polarity is coordinated by extrinsic signals. ..