cup-4

Summary

Gene Symbol: cup-4
Description: Acetylcholine receptor-like protein cup-4
Alias: Acetylcholine receptor-like protein cup-4
Species: Caenorhabditis elegans

Top Publications

  1. Fares H, Greenwald I. Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. Genetics. 2001;159:133-45 pubmed
  2. Patton A, Knuth S, Schaheen B, Dang H, Greenwald I, Fares H. Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans. Curr Biol. 2005;15:1045-50 pubmed
    ..Worms lacking CUP-4 have reduced phosphatidylinositol 4,5-bisphosphate levels at the plasma membrane, suggesting that CUP-4 regulates endocytosis through modulation of phospholipase C activity. ..
  3. Park S, Tedesco P, Johnson T. Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell. 2009;8:258-69 pubmed publisher
    ..These findings showed that a transcriptional shift from growth and maintenance towards the activation of cellular defense mechanisms was caused by the oxidative stress; many of these transcriptional alterations are SKN-1 dependent. ..
  4. Park S, Link C, Johnson T. Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J. 2010;24:383-92 pubmed publisher
    ..We conclude that two novel pathways, NLP-7 signaling and endocytosis by coelomocytes, are required for life extension under dietary restriction in C. elegans. ..