Gene Symbol: csr-1
Description: Chromosome-Segregation and RNAi deficient
Alias: Chromosome-Segregation and RNAi deficient
Species: Caenorhabditis elegans
Yigit E, Batista P, Bei Y, Pang K, Chen C, Tolia N, et al
. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell. 2006;127:747-57 pubmed
..Interestingly, these AGO proteins lack key residues required for mRNA cleavage. Our findings support a two-step model for RNAi, in which functionally and structurally distinct AGOs act sequentially to direct gene silencing. ..
Friend K, Campbell Z, Cooke A, Kroll Conner P, WICKENS M, Kimble J. A conserved PUF-Ago-eEF1A complex attenuates translation elongation. Nat Struct Mol Biol. 2012;19:176-83 pubmed publisher
..Together, these data suggest that a conserved PUF-Ago-eEF1A complex attenuates translation elongation. ..
Aoki K, Moriguchi H, Yoshioka T, Okawa K, Tabara H. In vitro analyses of the production and activity of secondary small interfering RNAs in C. elegans. EMBO J. 2007;26:5007-19 pubmed
..An Argonaute protein, CSR-1, is responsible for the Slicer activity induced by secondary-type siRNAs. Secondary rather than primary siRNAs may play a major role in the destabilization of target transcripts during RNAi in C. elegans. ..
Claycomb J, Batista P, Pang K, Gu W, Vasale J, Van Wolfswinkel J, et al
. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009;139:123-34 pubmed publisher
..Instead, our findings support a model in which CSR-1 complexes target protein-coding domains to promote their proper organization within the holocentric chromosomes of C. elegans. ..
Avgousti D, Palani S, Sherman Y, Grishok A. CSR-1 RNAi pathway positively regulates histone expression in C. elegans. EMBO J. 2012;31:3821-32 pubmed publisher
..Moreover, we demonstrate that increasing the dosage of histone genes rescues the lethality associated with depletion of CSR-1 and EGO-1. These results support a positive and direct effect of RNAi on histone gene expression. ..
Conine C, Moresco J, Gu W, Shirayama M, Conte D, Yates J, et al
. Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. Cell. 2013;155:1532-44 pubmed publisher
..Together, these findings suggest that C. elegans sperm transmit not only the genome but also epigenetic binary signals in the form of Argonaute/small RNA complexes that constitute a memory of gene expression in preceding generations. ..
Van Wolfswinkel J, Claycomb J, Batista P, Mello C, Berezikov E, Ketting R. CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. Cell. 2009;139:135-48 pubmed publisher
..The conserved nature of CDE-1 suggests that similar sorting mechanisms may operate in other animals, including mammals. ..
Robert V, Sijen T, van Wolfswinkel J, Plasterk R. Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev. 2005;19:782-7 pubmed
..Together with molecular data also presented in this study, these results suggest that in C. elegans repetitive sequences trigger transcriptional gene silencing using RNAi and chromatin factors. ..
Cecere G, Hoersch S, O Keeffe S, Sachidanandam R, Grishok A. Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape. Nat Struct Mol Biol. 2014;21:358-65 pubmed publisher
..On the basis of these findings, we propose that the CSR-1 pathway helps maintain the directionality of active transcription, thereby propagating the distinction between transcriptionally active and silent genomic regions...