csp-3

Summary

Gene Symbol: csp-3
Description: Non-catalytic caspase homolog csp-3
Alias: Non-catalytic caspase homolog csp-3
Species: Caenorhabditis elegans

Top Publications

  1. Geng X, Shi Y, Nakagawa A, Yoshina S, Mitani S, Shi Y, et al. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Nat Struct Mol Biol. 2008;15:1094-101 pubmed publisher
    ..However, CSP-3 does not block CED-3 activation induced by CED-4, nor does it inhibit the activity of the activated CED-3 protease. Therefore CSP-3 uses a previously unreported mechanism to protect cells from apoptosis. ..
  2. Geng X, Zhou Q, Kage Nakadai E, Shi Y, Yan N, Mitani S, et al. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Cell Death Differ. 2009;16:1385-94 pubmed publisher
    ..elegans caspase homologs use the same mechanism to prevent caspase autoactivation and apoptosis in different tissues, suggesting that this could be a generally applicable strategy for regulating caspase activation and apoptosis. ..
  3. Denning D, Hatch V, Horvitz H. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003341 pubmed publisher
    ..We conclude that both caspase-dependent and caspase-independent pathways promote apoptotic programmed cell death and the phagocytosis of cell corpses in parallel to the canonical apoptosis pathway involving CED-3 activation. ..