Gene Symbol: csn-5
Description: COP9 signalosome complex subunit 5
Alias: COP9 signalosome complex subunit 5
Species: Caenorhabditis elegans
Smith P, Leung Chiu W, Montgomery R, Orsborn A, Kuznicki K, Gressman Coberly E, et al
. The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein. Dev Biol. 2002;251:333-47 pubmed
..Similar to the loss of GLH-1 and GLH-4, loss of either CSN-5 or KGB-1 causes oogenesis to cease, but does not affect the initial assembly of P granules. ..
Orsborn A, Li W, McEwen T, Mizuno T, Kuzmin E, Matsumoto K, et al
. GLH-1, the C. elegans P granule protein, is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5. Development. 2007;134:3383-92 pubmed
..In addition, both KGB-1 and CSN-5 bind Vasa, a Drosophila germ granule component; therefore, similar regulatory mechanisms might be conserved from worms to flies. ..
Miller R, Qadota H, Stark T, Mercer K, Wortham T, Anyanful A, et al
. CSN-5, a component of the COP9 signalosome complex, regulates the levels of UNC-96 and UNC-98, two components of M-lines in Caenorhabditis elegans muscle. Mol Biol Cell. 2009;20:3608-16 pubmed publisher
..Taken together, we found that CSN-5 functions in muscle cells to regulate UNC-98 and -96, two M-line proteins. ..
Pintard L, Kurz T, Glaser S, Willis J, Peter M, Bowerman B. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Curr Biol. 2003;13:911-21 pubmed
..We conclude that both neddylation and deneddylation of CUL-3 is required for MEI-1 degradation and propose that cycles of CUL-3 neddylation and deneddylation are necessary for its ligase activity in vivo. ..
Ambroggio X, Rees D, Deshaies R. JAMM: a metalloprotease-like zinc site in the proteasome and signalosome. PLoS Biol. 2004;2:E2 pubmed publisher
..The active site-like architecture specified by the JAMM motif motivates structure-based approaches to the study of JAMM domain proteins and the development of therapeutic proteasome and signalosome inhibitors...
Kim J, Gabel H, Kamath R, Tewari M, Pasquinelli A, Rual J, et al
. Functional genomic analysis of RNA interference in C. elegans. Science. 2005;308:1164-7 pubmed
..Moreover, the physical interactions among these potential RNAi factors suggest links to other RNA-dependent gene regulatory pathways. ..
Tong X, Buechner M. CRIP homologues maintain apical cytoskeleton to regulate tubule size in C. elegans. Dev Biol. 2008;317:225-33 pubmed publisher
..EXC-9 and its nematode homologue act in polarized epithelial cells that must maintain great flexibility at their apical surface; our results suggest that CRIPs function to maintain cytoskeletal flexibility at the apical surface. ..
Dorfman M, Gomes J, O Rourke S, Bowerman B. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Genetics. 2009;182:1035-49 pubmed publisher
..Thus, when controlled properly for specificity, modifier screens using conditionally lethal C. elegans mutants can identify roles for nonessential but conserved genes in essential processes. ..
Brockway H, Balukoff N, Dean M, Alleva B, Smolikove S. The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans. PLoS Genet. 2014;10:e1004757 pubmed publisher
..The work described here supports a previously unknown role for the CSN/COP9 signalosome in chromosome behavior during meiotic prophase I. ..