Gene Symbol: crt-1
Species: Caenorhabditis elegans
Park B, Lee D, Yu J, Jung S, Choi K, Kim Y, et al
. Calreticulin, a calcium-binding molecular chaperone, is required for stress response and fertility in Caenorhabditis elegans. Mol Biol Cell. 2001;12:2835-45 pubmed
b>Calreticulin (CRT), a Ca(2+)-binding protein known to have many cellular functions, including regulation of Ca(2+) homoeostasis and chaperone activity, is essential for heart and brain development during embryogenesis in mice...
Lim Y, Lee D, Kalichamy K, Hong S, Michalak M, Ahnn J, et al
. Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans. Int J Biochem Cell Biol. 2014;53:399-408 pubmed publisher
..b>Calreticulin is a chaperone that facilitates protein folding in the ER lumen, and its gene expression is induced by ER ..
Xu K, Tavernarakis N, Driscoll M. Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum. Neuron. 2001;31:957-71 pubmed
..We report that null mutations in calreticulin suppress both mec-4(d)-induced cell death and the necrotic cell death induced by expression of a constitutively ..
Kales S, Fujiki K, Dixon B. Molecular cloning and characterization of calreticulin from rainbow trout ( Oncorhynchus mykiss). Immunogenetics. 2004;55:717-23 pubmed
b>Calreticulin (CRT) is a highly conserved, high-capacity, calcium-binding protein shared among vertebrates, invertebrates and higher plants...
Lee W, Lee T, Park B, Chang J, Yu J, Koo H, et al
. Caenorhabditis elegans calnexin is N-glycosylated and required for stress response. Biochem Biophys Res Commun. 2005;338:1018-30 pubmed
..Moreover, a double knockout mutant of calnexin and calreticulin exhibits additive severe defects...
Lee D, Singaravelu G, Park B, Ahnn J. Differential requirement of unfolded protein response pathway for calreticulin expression in Caenorhabditis elegans. J Mol Biol. 2007;372:331-40 pubmed
..b>Calreticulin is a calcium-binding chaperone located in the lumen of endoplasmic reticulum (ER)...
Zahreddine H, Zhang H, Diogon M, Nagamatsu Y, Labouesse M. CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development. Curr Biol. 2010;20:322-7 pubmed publisher
..We further characterized two genes encoding the chaperone CRT-1/calreticulin and the HECT domain E3 ubiquitin ligase EEL-1/HUWE1...