Gene Symbol: cpl-1
Description: CathePsin L family
Alias: CathePsin L family
Species: Caenorhabditis elegans
Products:     cpl-1

Top Publications

  1. Hashmi S, Britton C, Liu J, Guiliano D, Oksov Y, Lustigman S. Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans. J Biol Chem. 2002;277:3477-86 pubmed
    ..Similar localization of a related cathepsin L in the filarial nematode Onchocerca volvulus, eggshell and cuticle, suggests that some of the Ce-CPL-1 function during development may be conserved in other parasitic nematodes. ..
  2. Britton C, Murray L. Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans. J Cell Sci. 2004;117:5133-43 pubmed
    ..This study has relevance to the abnormal fusion and aggregation of lysosomes in cathepsin L-deficient mice and to other lysosomal disorders. ..
  3. Luke C, Pak S, Askew Y, Naviglia T, Askew D, Nobar S, et al. An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell. 2007;130:1108-19 pubmed
    ..These findings suggest that multiple noxious stimuli converge upon a peptidase-driven, core stress response pathway that, in the absence of serpin regulation, triggers a lysosomal-dependent necrotic cell death routine. ..
  4. Schmökel V, Memar N, Wiekenberg A, Trotzmüller M, Schnabel R, Döring F. Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos. Genetics. 2016;202:1071-83 pubmed publisher
    ..elegans embryos. Owing to the high levels of conservation, the identified genes are also useful in studies of embryonic lipid storage in other organisms. ..
  5. Richardson C, Kooistra T, Kim D. An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature. 2010;463:1092-5 pubmed publisher
    ..elegans development and indicate that an ancient, conserved role for XBP-1 may be to protect the host organism from the detrimental effects of mounting an innate immune response to microbes. ..
  6. Miedel M, Graf N, Stephen K, Long O, Pak S, Perlmutter D, et al. A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans. PLoS ONE. 2012;7:e40145 pubmed publisher
    ..elegans. This transgenic line will facilitate high-throughput genetic or pharmacological screens for ERAD modifiers using widefield epifluorescence microscopy. ..
  7. Xu M, Liu Y, Zhao L, Gan Q, Wang X, Yang C. The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans. Mol Biol Cell. 2014;25:2071-83 pubmed publisher
    ..Collectively, these findings establish CPL-1 as the leading lysosomal protease required for elimination of apoptotic cells in C. elegans. ..