Gene Symbol: cog 1
Description: hypothetical protein
Species: Caenorhabditis elegans
Palmer R, Inoue T, Sherwood D, Jiang L, Sternberg P. Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development. Dev Biol. 2002;252:202-13 pubmed
..Two mutant alleles of cog-1 differentially affect alternative transcripts and cause different phenotypes, suggesting that the two forms of cog-1 have distinct functions in C. elegans. ..
Johnston R, Chang S, Etchberger J, Ortiz C, Hobert O. MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision. Proc Natl Acad Sci U S A. 2005;102:12449-54 pubmed
..The interaction of miRNAs in double-negative feedback loops may not only be a means for miRNAs to regulate their own expression but may also represent a general paradigm for how terminal cell fates are selected and stabilized. ..
Fernandes J, Sternberg P. The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva. PLoS Genet. 2007;3:e69 pubmed
..We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types...
O Meara M, Bigelow H, Flibotte S, Etchberger J, Moerman D, Hobert O. Cis-regulatory mutations in the Caenorhabditis elegans homeobox gene locus cog-1 affect neuronal development. Genetics. 2009;181:1679-86 pubmed publisher
..The multiplicity of cis-regulatory elements may ensure the robustness of gene expression. ..
Sarin S, O Meara M, Flowers E, Antonio C, Poole R, Didiano D, et al
. Genetic screens for Caenorhabditis elegans mutants defective in left/right asymmetric neuronal fate specification. Genetics. 2007;176:2109-30 pubmed
..Taken together, our mutant screens identified a broad catalog of genes whose molecular characterization is expected to provide more insight into the complex genetic architecture of a left/right asymmetric neuronal cell fate decision. ..
Flowers E, Poole R, Tursun B, Bashllari E, Pe er I, Hobert O. The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegans. Development. 2010;137:1799-805 pubmed publisher
..We propose that Groucho-mediated gene regulatory events involve heteromeric complexes of distinct Groucho-like proteins. ..
Chang S, Johnston R, Hobert O. A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans. Genes Dev. 2003;17:2123-37 pubmed
..Our studies have thus identified transcriptional mediators of a putative L/R-asymmetric signaling event and suggest that vertebrate homologs of these proteins may have similar functions in regulating vertebrate brain asymmetries. ..