Gene Symbol: cmk-1
Description: Calcium/calmodulin-dependent protein kinase type 1
Alias: Calcium/calmodulin-dependent protein kinase type 1
Species: Caenorhabditis elegans

Top Publications

  1. Hook S, Means A. Ca(2+)/CaM-dependent kinases: from activation to function. Annu Rev Pharmacol Toxicol. 2001;41:471-505 pubmed
    ..Gene transcription has been chosen as the functional endpoint to illustrate the recent advances in Ca(2+)/CaM-mediated signal transduction mechanisms. ..
  2. Schild L, Zbinden L, Bell H, Yu Y, Sengupta P, Goodman M, et al. The balance between cytoplasmic and nuclear CaM kinase-1 signaling controls the operating range of noxious heat avoidance. Neuron. 2014;84:983-96 pubmed publisher
    ..Our results establish CaMKI as a key regulator of the operating range for nocifensive behaviors and suggest strategies for producing thermal analgesia through the regulation of CaMKI-dependent signaling. ..
  3. Moss B, Park L, Dahlberg C, Juo P. The CaM Kinase CMK-1 Mediates a Negative Feedback Mechanism Coupling the C. elegans Glutamate Receptor GLR-1 with Its Own Transcription. PLoS Genet. 2016;12:e1006180 pubmed publisher
    ..We propose a model in which synaptic activity regulates the nuclear localization of CMK-1 to mediate a negative feedback mechanism coupling GLR-1 activity with its own transcription. ..
  4. Eto K, Takahashi N, Kimura Y, Masuho Y, Arai K, Muramatsu M, et al. Ca(2+)/Calmodulin-dependent protein kinase cascade in Caenorhabditis elegans. Implication in transcriptional activation. J Biol Chem. 1999;274:22556-62 pubmed
    ..elegans and is functionally operated both in vitro and in intact cells, and it may be involved in Ca(2+)-dependent nuclear events such as transcriptional activation through phosphorylation of CREB. ..
  5. Satterlee J, Ryu W, Sengupta P. The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Curr Biol. 2004;14:62-8 pubmed
    ..We propose that the activation of distinct programs of AFD-specific gene expression at different temperatures by CMK-1 and TAX-4 enables C. elegans to sense and/or encode a memory for the T(c). ..
  6. Neal S, Takeishi A, O Donnell M, Park J, Hong M, Butcher R, et al. Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. elife. 2015;4: pubmed publisher
    ..These results identify mechanisms by which nutrient information is integrated in a small neuronal network to modulate neuroendocrine signaling and developmental plasticity. ..