cls-2

Summary

Gene Symbol: cls-2
Description: CLASP family of microtubule-binding proteins;Protein CLASP-2
Alias: CLASP family of microtubule-binding proteins;Protein CLASP-2
Species: Caenorhabditis elegans

Top Publications

  1. Espiritu E, Krueger L, Ye A, Rose L. CLASPs function redundantly to regulate astral microtubules in the C. elegans embryo. Dev Biol. 2012;368:242-54 pubmed publisher
    ..Further, we show that these spindle pole-positioning roles are independent of the CLS-2 binding proteins HCP-1 and HCP-2...
  2. Yang H, McNally K, McNally F. MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans. Dev Biol. 2003;260:245-59 pubmed
    ..These results indicate a direct role of microtubule severing in translocation of the meiotic spindle to the cortex. ..
  3. Dumont J, Oegema K, Desai A. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat Cell Biol. 2010;12:894-901 pubmed publisher
    ..We suggest that separation is controlled by a meiosis-specific chromosomal domain to coordinate cohesin removal and chromosome segregation. ..
  4. Maton G, Edwards F, Lacroix B, Stefanutti M, Laband K, Lieury T, et al. Kinetochore components are required for central spindle assembly. Nat Cell Biol. 2015;17:697-705 pubmed publisher
    ..Together, our results reveal an unexpected role for a conserved kinetochore protein network in coupling two critical events of cell division: chromosome segregation and cytokinesis. ..
  5. Cheeseman I, MacLeod I, Yates J, Oegema K, Desai A. The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation. Curr Biol. 2005;15:771-7 pubmed
    ..Our results establish that the key role of HCP-1/2 is to target CLASP(CLS-2) to kinetochores, and they support the recently proposed model that CLASP functions to promote the polymerization of kinetochore bound microtubules [4]. ..
  6. Bringmann H, Cowan C, Kong J, Hyman A. LET-99, GOA-1/GPA-16, and GPR-1/2 are required for aster-positioned cytokinesis. Curr Biol. 2007;17:185-91 pubmed
    ..We conclude that LET-99 and the G proteins define a molecular pathway required for aster-positioned cytokinesis. ..