Gene Symbol: che-3
Description: Cytoplasmic dynein 2 heavy chain 1
Alias: Cytoplasmic dynein 2 heavy chain 1
Species: Caenorhabditis elegans
Lewis J, Hodgkin J. Specific neuroanatomical changes in chemosensory mutants of the nematode Caenorhabditis elegans. J Comp Neurol. 1977;172:489-510 pubmed
..Our study illustrates the possibilities for genetic dissection of the development of a small set of nerves in a simple organism. ..
Starich T, Herman R, Kari C, Yeh W, Schackwitz W, Schuyler M, et al
. Mutations affecting the chemosensory neurons of Caenorhabditis elegans. Genetics. 1995;139:171-88 pubmed
..We have assigned 20 mutations to 13 new genes, called dyf-1 through dyf-13. We expect that the genes represented by dye-filing defective mutants are important for the differentiation of amphid and phasmid chemosensilla. ..
Vowels J, Thomas J. Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics. 1992;130:105-23 pubmed
..These results suggest that daf-11 is directly involved in chemosensory transduction essential for dauer formation, while the other Daf-c genes play roles downstream of the chemosensory step. ..
Golden J, Riddle D. A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A. 1984;81:819-23 pubmed
..These mutations appear to indirectly result in a ts phenotype by enhancing the expression of a wild-type ts developmental process. ..
Murakami M, Koga M, Ohshima Y. DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11. Mech Dev. 2001;109:27-35 pubmed
..Expression of daf-11 cDNA by cell specific promoters suggests that daf-11 acts cell autonomously in ASI chemosensory neurons for daf-7 expression. ..
Wicks S, de Vries C, van Luenen H, Plasterk R. CHE-3, a cytosolic dynein heavy chain, is required for sensory cilia structure and function in Caenorhabditis elegans. Dev Biol. 2000;221:295-307 pubmed
Haycraft C, Swoboda P, Taulman P, Thomas J, Yoder B. The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms. Development. 2001;128:1493-505 pubmed
..Overall, the data support a crucial role for osm-5 in a conserved ciliogenic pathway, most likely as a component of the IFT process. http://www.biologists.com/Development/movies/dev3342.html ..
Barr M, Sternberg P. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature. 1999;401:386-9 pubmed
..PKD-2, the C. elegans homologue of PKD2, is localized to the same neurons as LOV-1, suggesting that they function in the same pathway...
Signor D, Wedaman K, Orozco J, Dwyer N, Bargmann C, Rose L, et al
. Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegans. J Cell Biol. 1999;147:519-30 pubmed
..Thus, we propose that the class DHC1b cytoplasmic dynein, CHE-3, is specifically responsible for the retrograde transport of the anterograde motor, kinesin-II, and its cargo within sensory cilia, but not within dendrites. ..