che-13

Summary

Gene Symbol: che-13
Description: Intraflagellar transport protein che-13
Alias: Intraflagellar transport protein che-13
Species: Caenorhabditis elegans

Top Publications

  1. Ou G, Koga M, Blacque O, Murayama T, Ohshima Y, Schafer J, et al. Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell. 2007;18:1554-69 pubmed
  2. Vowels J, Thomas J. Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics. 1992;130:105-23 pubmed
    ..These results suggest that daf-11 is directly involved in chemosensory transduction essential for dauer formation, while the other Daf-c genes play roles downstream of the chemosensory step. ..
  3. Perkins L, Hedgecock E, Thomson J, Culotti J. Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev Biol. 1986;117:456-87 pubmed
    ..The cat-6 (e1861) mutation disrupts the tubular bodies of the CEP mechanocilia. A cryophilic thermotaxis mutant, ttx-1 (p767), lacks fingers on the AFD dendrite, suggesting this neuron is thermosensory. ..
  4. Starich T, Herman R, Kari C, Yeh W, Schackwitz W, Schuyler M, et al. Mutations affecting the chemosensory neurons of Caenorhabditis elegans. Genetics. 1995;139:171-88 pubmed
    ..We have assigned 20 mutations to 13 new genes, called dyf-1 through dyf-13. We expect that the genes represented by dye-filing defective mutants are important for the differentiation of amphid and phasmid chemosensilla. ..
  5. Williams C, Winkelbauer M, Schafer J, Michaud E, Yoder B. Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis. Mol Biol Cell. 2008;19:2154-68 pubmed publisher
    ..Together, these data suggest that the human homologues of the novel B9 genes B9D2 and B9D1 will be strong candidate loci for pathologies in human MKS, NPHP, and JBTS. ..
  6. Haycraft C, Schafer J, Zhang Q, Taulman P, Yoder B. Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation. Exp Cell Res. 2003;284:251-63 pubmed
    ..Overall, our data confirm that CHE-13 is an IFT protein and further that the IFT particle assembles in an ordered process through specific protein-protein interactions. ..
  7. Efimenko E, Blacque O, Ou G, Haycraft C, Yoder B, Scholey J, et al. Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia. Mol Biol Cell. 2006;17:4801-11 pubmed
    ..Importantly, the mouse orthologue of DYF-2, WDR19, also localizes to cilia, pointing to an important evolutionarily conserved role for this WDR protein in cilia development and function. ..