Gene Symbol: cha-1
Description: Choline O-acetyltransferase
Alias: Choline O-acetyltransferase
Species: Caenorhabditis elegans
Duerr J, Han H, Fields S, Rand J. Identification of major classes of cholinergic neurons in the nematode Caenorhabditis elegans. J Comp Neurol. 2008;506:398-408 pubmed
..Description of the normal pattern of cholinergic proteins and neurons will improve our understanding of the role of cholinergic neurons in the behavior and development of this model organism. ..
Lickteig K, Duerr J, Frisby D, Hall D, Rand J, Miller D. Regulation of neurotransmitter vesicles by the homeodomain protein UNC-4 and its transcriptional corepressor UNC-37/groucho in Caenorhabditis elegans cholinergic motor neurons. J Neurosci. 2001;21:2001-14 pubmed
..The temporal correlation of these events may mean that a common unc-4-dependent mechanism controls both the specificity of synaptic inputs as well as the strength of synaptic outputs for these motor neurons. ..
Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, et al
. Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans. Sci Rep. 2012;2:487 pubmed publisher
..These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues. ..
Mathews E, Mullen G, Manjarrez J, Rand J. Unusual regulation of splicing of the cholinergic locus in Caenorhabditis elegans. Genetics. 2015;199:729-37 pubmed publisher
..We have identified complementary elements at comparable locations in the genomes of representative species of other animal phyla; we suggest that this unusual regulatory mechanism may be a general feature of CGLs. ..
Rand J, Russell R. Properties and partial purification of choline acetyltransferase from the nematode Caenorhabditis elegans. J Neurochem. 1985;44:189-200 pubmed
..The Km for each substrate is also affected by salt, but in different manners from each other and the Vmax; the kinetic parameter Vmax/Km thus changes significantly as a function of the salt concentration. ..
Nguyen M, Alfonso A, Johnson C, Rand J. Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase. Genetics. 1995;140:527-35 pubmed
..Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions...
Clark S, Shurland D, Meyerowitz E, Bargmann C, van der Bliek A. A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans. Proc Natl Acad Sci U S A. 1997;94:10438-43 pubmed
..Using a dyn-1::lacZ gene fusion, a high level of dynamin expression was observed in motor neurons, intestine, and pharyngeal muscle. Our results suggest that dyn-1 function is required during development and for normal locomotion. ..
Zhang M, Chung S, Fang Yen C, Craig C, Kerr R, Suzuki H, et al
. A self-regulating feed-forward circuit controlling C. elegans egg-laying behavior. Curr Biol. 2008;18:1445-55 pubmed publisher
..This microcircuit motif is common in the C. elegans nervous system, as well as in the mammalian cortex; thus, understanding its functional properties in C. elegans may provide insight into its computational role in more complex brains. ..
Xu Y, Ren X, Quinn C, Wadsworth W. Axon response to guidance cues is stimulated by acetylcholine in Caenorhabditis elegans. Genetics. 2011;189:899-906 pubmed publisher
..Together, our results show that for specific neurons acetylcholine plays an important role in vivo as a modulator of axon responses to guidance cues. ..