Gene Symbol: ces-2
Description: Cell death specification protein 2
Alias: Cell death specification protein 2
Species: Caenorhabditis elegans

Top Publications

  1. Metzstein M, Hengartner M, Tsung N, Ellis R, Horvitz H. Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2. Nature. 1996;382:545-7 pubmed
    ..On the basis of these observations, we suggest that some CES-2/PAR family transcription factors are evolutionary conserved regulators of programmed cell death. ..
  2. Metzstein M, Horvitz H. The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein. Mol Cell. 1999;4:309-19 pubmed
    ..Our results suggest that a transcriptional cascade controls the deaths of specific cells in C. elegans. ..
  3. Thellmann M, Hatzold J, Conradt B. The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins. Development. 2003;130:4057-71 pubmed
    ..In ces-1(gf) animals, CES-1 might therefore prevent the death of the NSM sister cells by successfully competing with HLH-2/HLH-3 for binding to the egl-1 locus. ..
  4. Ellis R, Horvitz H. Two C. elegans genes control the programmed deaths of specific cells in the pharynx. Development. 1991;112:591-603 pubmed
    ..These mutations do not affect most other cell deaths. Genetic studies indicate that ces-1 and ces-2 affect the fates of the NSM sisters by regulating the genes required for all programmed cell deaths to occur. ..
  5. Wang X, Jia H, Chamberlin H. The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a cell-specific target gene in C. elegans. Dev Biol. 2006;289:456-65 pubmed
    ..Thus, the two bZip proteins function together as one of several inputs that influence the spatial and temporal regulation of lin-48. ..
  6. Hatzold J, Conradt B. Control of apoptosis by asymmetric cell division. PLoS Biol. 2008;6:e84 pubmed publisher
    ..Furthermore, based on our results, we propose that this pathway directly controls the apoptotic fate in C. elegans, and possibly other animals as well. ..
  7. Erdélyi P, Borsos E, Takacs Vellai K, Kovacs T, Kovacs A, Sigmond T, et al. Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J Cell Sci. 2011;124:1510-8 pubmed publisher
    ..The identification of apoptosis and autophagy as compensatory cellular pathways in C. elegans might help us to understand how dysregulated PCD in humans can lead to diverse pathologies, including cancer, neurodegeneration and diabetes. ..