Gene Symbol: ced 7
Description: ABC transporter ced-7;hypothetical protein
Alias: ABC transporter ced-7;hypothetical protein
Species: Caenorhabditis elegans
Ellis R, Jacobson D, Horvitz H. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 1991;129:79-94 pubmed
..These observations suggest that these two sets of genes are involved in distinct and partially redundant processes that act in the engulfment of cell corpses...
Wu Y, Horvitz H. The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. Cell. 1998;93:951-60 pubmed
Mapes J, Chen Y, Kim A, Mitani S, Kang B, Xue D. CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells. Curr Biol. 2012;22:1267-75 pubmed publisher
..In addition, some living cells such as macrophages also express exPS...
Denning D, Hatch V, Horvitz H. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003341 pubmed publisher
..We conclude that both caspase-dependent and caspase-independent pathways promote apoptotic programmed cell death and the phagocytosis of cell corpses in parallel to the canonical apoptosis pathway involving CED-3 activation. ..
Cabello J, Neukomm L, Günesdogan U, Burkart K, Charette S, Lochnit G, et al
. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010;8:e1000297 pubmed publisher
..Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton. ..
Neukomm L, Nicot A, Kinchen J, Almendinger J, Pinto S, Zeng S, et al
. The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans. Development. 2011;138:2003-14 pubmed publisher
..Finally, we show that the CED-12 PH domain can bind to PtdIns(3,5)P(2) (one target of MTM-1 phosphatase activity), suggesting that MTM-1 might regulate CED-12 recruitment to the plasma membrane. ..
Nichols A, Meelkop E, Linton C, Giordano Santini R, Sullivan R, Donato A, et al
. The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C.Â elegans Neurons. Cell Rep. 2016;14:1673-1683 pubmed publisher
..Thus, our results reveal the existence of a WLD(S)/Nmnat-independent axonal degeneration pathway, conservation of the axonal clearance machinery, and a function for CED-7 and NRF-5 in this process. ..
Grau G, Chimini G. Immunopathological consequences of the loss of engulfment genes: the case of ABCA1. J Soc Biol. 2005;199:199-206 pubmed
..The ABCA1 transporter thus appears to control susceptibility to CM, thereby providing new insights in its pathophysiological mechanisms and potential new therapeutic avenues...
Chen Y, Mapes J, Lee E, Skeen Gaar R, Xue D. Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization. Nat Commun. 2013;4:2726 pubmed publisher
..elegans. Our finding identifies a crucial link between caspase activation and PS externalization, which triggers phagocytosis of apoptotic cells. ..