ced-6

Summary

Gene Symbol: ced-6
Description: Cell death protein 6
Alias: Cell death protein 6
Species: Caenorhabditis elegans

Top Publications

  1. Liu Q, Hengartner M. Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans. Cell. 1998;93:961-72 pubmed
    ..Our data suggest that CED-6 is an adaptor molecule acting in a signal transduction pathway that specifically mediates the recognition and engulfment of apoptotic cells. ..
  2. Kinchen J, Cabello J, Klingele D, Wong K, Feichtinger R, Schnabel H, et al. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature. 2005;434:93-9 pubmed
  3. Ellis R, Jacobson D, Horvitz H. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 1991;129:79-94 pubmed
    ..These observations suggest that these two sets of genes are involved in distinct and partially redundant processes that act in the engulfment of cell corpses...
  4. Su H, Nakada Tsukui K, Tosello Trampont A, Li Y, Bu G, Henson P, et al. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem. 2002;277:11772-9 pubmed
    ..These studies suggest a physical link between CED-1 or CD91/LRP and the adapter protein CED-6/GULP during engulfment of apoptotic cells and further elucidate the pathway suggested by the genetic studies. ..
  5. Cabello J, Neukomm L, G├╝nesdogan U, Burkart K, Charette S, Lochnit G, et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010;8:e1000297 pubmed publisher
    ..Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton. ..
  6. Zou W, Lu Q, Zhao D, Li W, Mapes J, Xie Y, et al. Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet. 2009;5:e1000679 pubmed publisher
    ..We propose that MTM-1 negatively regulates cell corpse engulfment through the CED-5/CED-12/CED-10 module by dephosphorylating PtdIns(3)P on the plasma membrane. ..
  7. Neukomm L, Nicot A, Kinchen J, Almendinger J, Pinto S, Zeng S, et al. The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans. Development. 2011;138:2003-14 pubmed publisher
    ..Finally, we show that the CED-12 PH domain can bind to PtdIns(3,5)P(2) (one target of MTM-1 phosphatase activity), suggesting that MTM-1 might regulate CED-12 recruitment to the plasma membrane. ..
  8. Denning D, Hatch V, Horvitz H. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003341 pubmed publisher
    ..We conclude that both caspase-dependent and caspase-independent pathways promote apoptotic programmed cell death and the phagocytosis of cell corpses in parallel to the canonical apoptosis pathway involving CED-3 activation. ..
  9. Chen D, Jian Y, Liu X, Zhang Y, Liang J, Qi X, et al. Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003517 pubmed publisher
    ..These findings reveal a non-classical role of clathrin and AP2 and establish them as indispensable regulators in phagocytic receptor-mediated apoptotic cell clearance...

More Information

Publications10

  1. Chen Y, Mapes J, Lee E, Skeen Gaar R, Xue D. Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization. Nat Commun. 2013;4:2726 pubmed publisher
    ..elegans. Our finding identifies a crucial link between caspase activation and PS externalization, which triggers phagocytosis of apoptotic cells. ..