Gene Symbol: ced-12
Description: Cell death abnormality protein 12;hypothetical protein
Alias: Cell death abnormality protein 12;hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Gumienny T, Brugnera E, Tosello Trampont A, Kinchen J, Haney L, Nishiwaki K, et al. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell. 2001;107:27-41 pubmed
    ..These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals. ..
  2. Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz H. The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. Dev Cell. 2001;1:477-89 pubmed
    ..We propose that through interactions with membranes and with a CED-2/CED-5 protein complex, CED-12 regulates Rho/Rac GTPase signaling and leads to cytoskeletal reorganization by an evolutionarily conserved mechanism. ..
  3. Wang X, Wu Y, Fadok V, Lee M, Gengyo Ando K, Cheng L, et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science. 2003;302:1563-6 pubmed
    ..Our findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis. ..
  4. Chung S, Gumienny T, Hengartner M, Driscoll M. A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans. Nat Cell Biol. 2000;2:931-7 pubmed
  5. Kinchen J, Cabello J, Klingele D, Wong K, Feichtinger R, Schnabel H, et al. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature. 2005;434:93-9 pubmed
  6. Nishiwaki K, Kubota Y, Chigira Y, Roy S, Suzuki M, Schvarzstein M, et al. An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans. Nat Cell Biol. 2004;6:31-7 pubmed
    ..Our findings indicate that an NDPase affects organ morphogenesis through glycosylation of the MIG-17 ADAM protease. ..
  7. deBakker C, Haney L, Kinchen J, Grimsley C, Lu M, Klingele D, et al. Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr Biol. 2004;14:2208-16 pubmed
    ..This work also identifies ARM repeats within CED-12/ELMO and their role in linking RhoG and Rac, two GTPases that function in tandem during engulfment. ..
  8. Cabello J, Neukomm L, Günesdogan U, Burkart K, Charette S, Lochnit G, et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010;8:e1000297 pubmed publisher
    ..Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton. ..
  9. Akakura S, Kar B, Singh S, Cho L, Tibrewal N, Sanokawa Akakura R, et al. C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF. J Cell Physiol. 2005;204:344-51 pubmed
    ..Studies with W276K CrkII may offer a unique opportunity to study the structure and function of the DOCK180/ELMO Rac-GEF. ..

More Information


  1. Wu Y, Tsai M, Cheng L, Chou C, Weng N. C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. Dev Cell. 2001;1:491-502 pubmed
    ..We suggest that CED-12 counterparts in higher organisms regulate cytoskeleton dynamics, as CED-12 does in C. elegans. ..
  2. Grimsley C, Kinchen J, Tosello Trampont A, Brugnera E, Haney L, Lu M, et al. Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J Biol Chem. 2004;279:6087-97 pubmed
    ..This finding suggests that Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 rather than generalized Rac activation plays a role in cell migration. ..
  3. Lu M, Kinchen J, Rossman K, Grimsley C, deBakker C, Brugnera E, et al. PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nat Struct Mol Biol. 2004;11:756-62 pubmed
    ..These data reveal a new mode of action of PH domains and a novel, evolutionarily conserved mechanism by which a bipartite GEF can activate Rac. ..
  4. Neukomm L, Nicot A, Kinchen J, Almendinger J, Pinto S, Zeng S, et al. The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans. Development. 2011;138:2003-14 pubmed publisher
    ..Finally, we show that the CED-12 PH domain can bind to PtdIns(3,5)P(2) (one target of MTM-1 phosphatase activity), suggesting that MTM-1 might regulate CED-12 recruitment to the plasma membrane. ..
  5. Chen Y, Mapes J, Lee E, Skeen Gaar R, Xue D. Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization. Nat Commun. 2013;4:2726 pubmed publisher
    ..elegans. Our finding identifies a crucial link between caspase activation and PS externalization, which triggers phagocytosis of apoptotic cells. ..