ced-10

Summary

Gene Symbol: ced-10
Description: Ras-related protein ced-10
Alias: Ras-related protein ced-10
Species: Caenorhabditis elegans

Top Publications

  1. Kubiseski T, Culotti J, Pawson T. Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo. Mol Cell Biol. 2003;23:6823-35 pubmed
    ..These results suggest that the UNC-73B PH domain plays distinct roles in targeting and promoting GEF activity towards the Rac GTPase, both of which are important for the directed movements of motorneurons in vivo. ..
  2. Cabello J, Neukomm L, Günesdogan U, Burkart K, Charette S, Lochnit G, et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010;8:e1000297 pubmed publisher
    ..Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton. ..
  3. Lundquist E, Reddien P, Hartwieg E, Horvitz H, Bargmann C. Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development. 2001;128:4475-88 pubmed
    ..CED-5 DOCK180, which acts with CED-10 Rac in cell-corpse phagocytosis, acted with MIG-2 but not CED-10 in axon pathfinding. Thus, distinct regulatory proteins modulate Rac activation and function in different developmental processes. ..
  4. Kinchen J, Cabello J, Klingele D, Wong K, Feichtinger R, Schnabel H, et al. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature. 2005;434:93-9 pubmed
  5. Wang X, Wu Y, Fadok V, Lee M, Gengyo Ando K, Cheng L, et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science. 2003;302:1563-6 pubmed
    ..Our findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis. ..
  6. Chen W, Lim H, Lim L. A new member of the ras superfamily, the rac1 homologue from Caenorhabditis elegans. Cloning and sequence analysis of cDNA, pattern of developmental expression, and biochemical characterization of the protein. J Biol Chem. 1993;268:320-4 pubmed
  7. Neukomm L, Frei A, Cabello J, Kinchen J, Zaidel Bar R, Ma Z, et al. Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans. Nat Cell Biol. 2011;13:79-86 pubmed publisher
    ..We propose that C. elegans uses the engulfment machinery as part of a primitive, but evolutionarily conserved, survey mechanism that identifies and removes unfit cells within a tissue. ..
  8. Shakir M, Gill J, Lundquist E. Interactions of UNC-34 Enabled with Rac GTPases and the NIK kinase MIG-15 in Caenorhabditis elegans axon pathfinding and neuronal migration. Genetics. 2006;172:893-913 pubmed
    ..MIG-2 Rac, which acts with CED-10 Rac, RAC-2 Rac, and UNC-34 Ena in axon pathfinding and cell migration, also acts with MIG-15 in PQR directional migration. ..
  9. Ellis R, Jacobson D, Horvitz H. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 1991;129:79-94 pubmed
    ..These observations suggest that these two sets of genes are involved in distinct and partially redundant processes that act in the engulfment of cell corpses...

More Information

Publications30

  1. Reddien P, Horvitz H. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol. 2000;2:131-6 pubmed
    ..We propose that CED-2/CrkII and CED-5/DOCK180 function to activate CED-10/Rac in a GTPase signalling pathway that controls the polarized extension of cell surfaces. ..
  2. Chen W, Chen S, Yap S, Lim L. The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation. J Biol Chem. 1996;271:26362-8 pubmed
    ..Interestingly, CeRac1 and CDC42Ce are found at the same location, which might point to their common involvement in hypodermal cell fusion, a crucial morphogenetic event for nematode development. ..
  3. Yang Y, Lu J, Rovnak J, Quackenbush S, Lundquist E. SWAN-1, a Caenorhabditis elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function. Genetics. 2006;174:1917-32 pubmed
    ..While broadly conserved across species, SWAN-1 family members show no sequence similarity to previously known Rac inhibitors. ..
  4. Akakura S, Kar B, Singh S, Cho L, Tibrewal N, Sanokawa Akakura R, et al. C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF. J Cell Physiol. 2005;204:344-51 pubmed
    ..Studies with W276K CrkII may offer a unique opportunity to study the structure and function of the DOCK180/ELMO Rac-GEF. ..
  5. Gabel C, Antoine F, Antonie F, Chuang C, Samuel A, Chang C. Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans. Development. 2008;135:1129-36 pubmed publisher
    ..Thus, C. elegans may be used as a genetic system to characterize novel cellular and molecular mechanisms underlying adult-stage nervous system regeneration. ..
  6. Canman J, Lewellyn L, Laband K, Smerdon S, Desai A, Bowerman B, et al. Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science. 2008;322:1543-6 pubmed publisher
    ..Thus, inactivation of Rac by centralspindlin functions in parallel with RhoA activation to drive contractile ring constriction during cytokinesis. ..
  7. Wu Y, Cheng T, Lee M, Weng N. Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth. Dev Biol. 2002;250:145-55 pubmed
    ..However, neither ced-2/crkII nor ced-5/dock180 is involved in amphid axon outgrowth. Therefore, distinct rac regulators control ced-10 and mig-2 differentially in various cellular processes. ..
  8. Dalpé G, Tarsitano M, Persico M, Zheng H, Culotti J. C. elegans PVF-1 inhibits permissive UNC-40 signalling through CED-10 GTPase to position the male ray 1 sensillum. Development. 2013;140:4020-30 pubmed publisher
    ..These data report the first case of VEGF-induced inhibition of the netrin signalling and a molecular conservation of VEGF function from worms to humans. ..
  9. Quinn C, Pfeil D, Wadsworth W. CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin. Curr Biol. 2008;18:808-13 pubmed publisher
    ..We propose that the interaction between activated CED-10/Rac1 and MIG-10/lamellipodin triggers local cytoskeletal assembly and polarizes outgrowth activity in response to UNC-6/netrin. ..
  10. Locke C, Kautu B, Berry K, Lee S, Caldwell K, Caldwell G. Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission. Genetics. 2009;183:1357-72 pubmed publisher
    ..elegans. ..
  11. Doi M, Minematsu H, Kubota Y, Nishiwaki K, Miyamoto M. The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans. Development. 2013;140:3435-44 pubmed publisher
    ..These results strongly suggest that RIN-1 acts as an effector for CED-10/Rac1 and regulates actin remodeling in response to restricted guidance cues. ..
  12. Neukomm L, Nicot A, Kinchen J, Almendinger J, Pinto S, Zeng S, et al. The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans. Development. 2011;138:2003-14 pubmed publisher
    ..Finally, we show that the CED-12 PH domain can bind to PtdIns(3,5)P(2) (one target of MTM-1 phosphatase activity), suggesting that MTM-1 might regulate CED-12 recruitment to the plasma membrane. ..
  13. Guan L, Ma X, Zhang J, Liu J, Wang Y, Ding M. The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions. PLoS Genet. 2016;12:e1006163 pubmed publisher
    ..Hence, by coupling membrane expansion to Rac1-mediated actin dynamics, CHDP-1 promotes the formation of cellular protrusions in vivo. ..
  14. Qadota H, Miyauchi T, Nahabedian J, Stirman J, Lu H, Amano M, et al. PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans. J Mol Biol. 2011;407:222-31 pubmed publisher
    ..The genomic deletion of pkn-1 also showed a defect in force transmission. These results suggest that PKN-1 functions as a regulator of muscle contraction-relaxation and as a component of the force transmission mechanism. ..
  15. Kishore R, Sundaram M. ced-10 Rac and mig-2 function redundantly and act with unc-73 trio to control the orientation of vulval cell divisions and migrations in Caenorhabditis elegans. Dev Biol. 2002;241:339-48 pubmed
    ..We discuss the similarities and differences between the cellular defects seen in Rac mutants and let-60 Ras or lin-17 Frizzled mutants. ..
  16. Meighan C, Schwarzbauer J. Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors. Genes Dev. 2007;21:1615-20 pubmed
    ..These results demonstrate concomitant, but distinct roles in migration for each integrin. Notably, transcriptional control of migration termination provides a new mechanism for regulation of morphogenesis and organ size. ..
  17. Sun L, Liu O, Desai J, Karbassi F, Sylvain M, Shi A, et al. CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2. PLoS Genet. 2012;8:e1002785 pubmed publisher
  18. Liu Z, Nukazuka A, Takagi S. Improved method for visualizing cells revealed dynamic morphological changes of ventral neuroblasts during ventral cleft closure of Caenorhabditis elegans. Dev Growth Differ. 2007;49:49-59 pubmed
    ..Using this method we, for the first time, document the dynamic changes in the morphology of ventral neuroblasts in vivo during ventral cleft closure. ..
  19. Caruso M, Jenna S, Beaulne S, Lee E, Bergeron A, Chauve C, et al. Biochemical clustering of monomeric GTPases of the Ras superfamily. Mol Cell Proteomics. 2005;4:936-44 pubmed
    ..Hence we propose a novel phylobiochemical classification of the Ras superfamily of GTPases. ..
  20. Walck Shannon E, Reiner D, Hardin J. Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans. Development. 2015;142:3549-60 pubmed publisher
    ..CRML-1 genetically suppresses UNC-73 function and, indirectly, actin polymerization. This network identifies a novel, molecularly conserved cassette that regulates epithelial intercalation via basolateral protrusive activity. ..
  21. Cabello J, Sämann J, Gomez Orte E, Erazo T, Coppa A, Pujol A, et al. PDR-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in Caenorhabditis elegans. Cell Death Dis. 2014;5:e1120 pubmed publisher
    ..Our genetic and biochemical studies indicate that PDR-1 inhibits apoptotic cell engulfment and DTC migration by ubiquitylating CED-10 for degradation. ..