ced-1

Summary

Gene Symbol: ced-1
Description: Cell death abnormality protein 1
Alias: Cell death abnormality protein 1
Species: Caenorhabditis elegans

Top Publications

  1. Kritikou E, Milstein S, Vidalain P, Lettre G, Bogan E, Doukoumetzidis K, et al. C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival. Genes Dev. 2006;20:2279-92 pubmed
    ..elegans germline and functions as a negative regulator of the MAPK signaling pathway during vulval development and in muscle cells. ..
  2. Ellis R, Jacobson D, Horvitz H. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 1991;129:79-94 pubmed
    ..These observations suggest that these two sets of genes are involved in distinct and partially redundant processes that act in the engulfment of cell corpses...
  3. Kinchen J, Cabello J, Klingele D, Wong K, Feichtinger R, Schnabel H, et al. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Nature. 2005;434:93-9 pubmed
  4. Yu X, Odera S, Chuang C, Lu N, Zhou Z. C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. Dev Cell. 2006;10:743-57 pubmed
  5. Su H, Nakada Tsukui K, Tosello Trampont A, Li Y, Bu G, Henson P, et al. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem. 2002;277:11772-9 pubmed
    ..These studies suggest a physical link between CED-1 or CD91/LRP and the adapter protein CED-6/GULP during engulfment of apoptotic cells and further elucidate the pathway suggested by the genetic studies. ..
  6. Mapes J, Chen Y, Kim A, Mitani S, Kang B, Xue D. CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells. Curr Biol. 2012;22:1267-75 pubmed publisher
    ..In addition, some living cells such as macrophages also express exPS...
  7. Wang X, Li W, Zhao D, Liu B, Shi Y, Chen B, et al. Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nat Cell Biol. 2010;12:655-64 pubmed publisher
    ..TTR-52 is therefore the first bridging molecule identified in C. elegans that mediates recognition of apoptotic cells by crosslinking the PtdSer 'eat me' signal with the phagocyte receptor CED-1. ..
  8. Yu X, Lu N, Zhou Z. Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells. PLoS Biol. 2008;6:e61 pubmed publisher
  9. Chen D, Xiao H, Zhang K, Wang B, Gao Z, Jian Y, et al. Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Science. 2010;327:1261-4 pubmed publisher
    ..Thus, retromer is an essential mediator of apoptotic cell clearance by regulating phagocytic receptor(s) during cell corpse engulfment. ..

More Information

Publications21

  1. Zhou Z, Hartwieg E, Horvitz H. CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans. Cell. 2001;104:43-56 pubmed
    ..We suggest that the ABC transporter CED-7 promotes cell corpse recognition by CED-1, possibly by exposing a phospholipid ligand on the surfaces of cell corpses...
  2. Haskins K, Russell J, Gaddis N, Dressman H, Aballay A. Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. Dev Cell. 2008;15:87-97 pubmed publisher
    ..The results indicate that unfolded protein response genes, regulated in a CED-1-dependent manner, are involved in the C. elegans immune response to live bacteria. ..
  3. Hedgecock E, Sulston J, Thomson J. Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans. Science. 1983;220:1277-9 pubmed
    ..With few exceptions, these cells still die, suggesting that, in nematodes, engulfment is not necessary for most programmed deaths. Instead, these deaths appear to occur by cell suicide. ..
  4. Denning D, Hatch V, Horvitz H. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003341 pubmed publisher
    ..We conclude that both caspase-dependent and caspase-independent pathways promote apoptotic programmed cell death and the phagocytosis of cell corpses in parallel to the canonical apoptosis pathway involving CED-3 activation. ..
  5. Kang Y, Zhao D, Liang H, Liu B, Zhang Y, Liu Q, et al. Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment. Genes Dev. 2012;26:1339-50 pubmed publisher
    ..Our results reveal the first full-length structure of a bridging molecule and the mechanism underlying bridging molecule-mediated apoptotic cell recognition. ..
  6. Lu N, Shen Q, Mahoney T, Liu X, Zhou Z. Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling. Mol Biol Cell. 2011;22:354-74 pubmed publisher
  7. Chen Y, Mapes J, Lee E, Skeen Gaar R, Xue D. Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization. Nat Commun. 2013;4:2726 pubmed publisher
    ..elegans. Our finding identifies a crucial link between caspase activation and PS externalization, which triggers phagocytosis of apoptotic cells. ..
  8. Cabello J, Neukomm L, Günesdogan U, Burkart K, Charette S, Lochnit G, et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010;8:e1000297 pubmed publisher
    ..Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton. ..
  9. Means T, Mylonakis E, Tampakakis E, Colvin R, Seung E, Puckett L, et al. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med. 2009;206:637-53 pubmed publisher
    ..Binding of these pathogens to SCARF1 and CD36 was beta-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are beta-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens. ..
  10. Neukomm L, Zeng S, Frei A, Huegli P, Hengartner M. Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. elegans. Cell Death Differ. 2014;21:845-53 pubmed publisher
    ..elegans. ..
  11. Sahu S, Lewis J, Patel I, Bozdag S, Lee J, Leclerc J, et al. Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans. PLoS ONE. 2012;7:e38200 pubmed publisher
    ..Our results suggest that VCC is a major virulence factor, which induces a wide variety of immune response- related genes during V. cholerae infection in C. elegans...
  12. Gronski M, Kinchen J, Juncadella I, Franc N, Ravichandran K. An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response. Cell Death Differ. 2009;16:1323-31 pubmed publisher