Gene Symbol: cebp-1
Description: C/EBP (CCAAT/enhancer-binding protein) homolog
Alias: C/EBP (CCAAT/enhancer-binding protein) homolog
Species: Caenorhabditis elegans
Yan D, Wu Z, Chisholm A, Jin Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell. 2009;138:1005-18 pubmed publisher
..Our findings identify the DLK-1 pathway as a regulator of mRNA stability in synapse formation and maintenance and also in adult axon regeneration. ..
Nix P, Hisamoto N, Matsumoto K, Bastiani M. Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways. Proc Natl Acad Sci U S A. 2011;108:10738-43 pubmed publisher
..These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK). ..
Li C, Hisamoto N, Matsumoto K. Axon Regeneration Is Regulated by Ets-C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca2+ Signaling Pathways. PLoS Genet. 2015;11:e1005603 pubmed publisher
..Furthermore, activation of both cAMP and Ca2+ signaling is required for activation of svh-2 expression. Thus, the cAMP/Ca2+ signaling pathways cooperatively activate the JNK pathway, which then promotes axon regeneration. ..
McEwan D, Feinbaum R, Stroustrup N, Haas W, Conery A, Anselmo A, et al
. Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway. BMC Biol. 2016;14:105 pubmed
..Because NIPI-3 and CEBP-1 are also essential for C. elegans development, NIPI-3 is analogous to other key innate immune signaling molecules such as the Toll receptors in Drosophila that have an independent role during development. ..
Kim K, Thakur N, Piggott C, Omi S, Polanowska J, Jin Y, et al
. Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development. BMC Biol. 2016;14:104 pubmed
..In doing so, it keeps innate immunity in check and ensures proper organismal development. ..
Sharifnia P, Kim K, Wu Z, Jin Y. Distinct cis elements in the 3' UTR of the C. elegans cebp-1 mRNA mediate its regulation in neuronal development. Dev Biol. 2017;429:240-248 pubmed publisher
..Our data reveal multiple cis elements within cebp-1's 3' UTR that help to optimize CEBP-1 expression levels in neuronal development. ..